Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization.

Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, discomfort, and changes in bowel habits. The mechanism underlying IBS remains unclear, and little evidence exists for clarifying the causal relationship between blood metabolites and IBS.

Methods: We conducted a Mendelian randomization (MR) study using two samples.