Publications by authors named "Zuhal Karalı"
Article Synopsis
- - DiGeorge syndrome (DGS) is a common microdeletion syndrome that impacts various body systems such as the heart, nervous, and immune systems; this study evaluated clinical and neurocognitive aspects of 52 DGS patients.
- - Out of the 52 patients, the median age was about 10.5 years, with partial DGS noted in those who survived; 15 patients did not survive during the study period.
- - Significant neurological issues were identified, including brain abnormalities in 72% of patients and various neuropsychological impairments, highlighting the need for awareness and tailored care for these individuals.
MHC Class II Deficiency: Clinical, Immunological, and Genetic Insights in a Large Multicenter Cohort.
J Allergy Clin Immunol Pract
September 2024
Background: Major histocompatibility complex class II deficiency, a combined immunodeficiency, results from loss of HLA class II expression on antigen-presenting cells. Currently, hematopoietic stem cell transplantation stands as the sole curative approach, although factors influencing patient outcomes remain insufficiently explored.
Objectives: To elucidate the clinical, immunologic, and genetic profiles associated with MHC-II deficiency and identify prognostic indicators that affect survival rates.
Neurological involvement in patients with primary immunodeficiency.
Allergol Immunopathol (Madr)
January 2024
Article Synopsis
- - Primary immunodeficiency diseases (PID) are associated with recurrent infections and can significantly impact neurological health, with conditions like Ataxia-Telangiectasia, Nijmegen breakage syndrome, and PNP deficiency demonstrating direct neurological involvement.
- - A study analyzed 108 PID patients and found that the median age for neurological issues was 7 years, with Di George Syndrome and common variable immunodeficiency being the most prevalent.
- - The results revealed that 99% of patients had central nervous system involvement, with cognitive delays, epilepsy, and ataxia being common outcomes; MRI scans of the brain showed abnormalities in 74% of the patients, highlighting various neurological disorders.
Background: LPS-responsive beige-like anchor (LRBA) deficiency (LRBA) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) insufficiency (CTLA4) are mechanistically overlapped diseases presenting with recurrent infections and autoimmunity. The effectiveness of different treatment regimens remains unknown.
Objective: Our aim was to determine the comparative efficacy and long-term outcome of therapy with immunosuppressants, CTLA4-immunoglobulin (abatacept), and hematopoietic stem cell transplantation (HSCT) in a single-country multicenter cohort of 98 patients with a 5-year median follow-up.
Introduction: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare severe hypersensitivity reactions that lead to epithelial sloughing. Studies investigating the chronic multisystem effects of these syndromes and assessing patients in terms of quality of life (QOL), depression, and anxiety in the pediatric population are limited. In this study, we aimed to investigate the long-term effects of these diseases from a multisystem perspective.
View Article and Find Full Text PDFIncreased health literacy (HL) improves the management of chronic diseases. Data on the HL levels of adolescents with asthma are limited. In this study, we aimed to investigate the HL levels of adolescents with asthma and the effect of HL levels on asthma control.
View Article and Find Full Text PDFBackground: The coronavirus disease 2019 (COVID-19) pandemic is affecting people at any age and there is limited information about the effect of the COVID-19 pandemic on quality of life (QoL) in adolescents with asthma. In the present study, it was aimed to assess the attitudes of adolescents with asthma toward the COVID-19 pandemic and determine the effects of the pandemic on their QoL.
Methods: In total, 125 adolescents with asthma and 98 healthy adolescents participated in the present study.
Aim: To determine the frequency of sinopulmonary infections, detect changes in the respiratory system, and measure functional capacity of the lungs in our patients with humoral immunodeficiency.
Material And Methods: Fifty-six patients with humoral immunodeficiency were enrolled in this study. The clinical, laboratory, and radiologic data, and pulmonary function tests of the subjects were evaluated from their file records, retrospectively.
Neonatal outcomes of premature infants born to preeclamptic mothers.
J Matern Fetal Neonatal Med
May 2010
Objective: Only limited studies with conflicting results are available on neonatal morbidity and mortality in infants born to preeclamptic mothers. The objective of this study was to evaluate neonatal morbidity and mortality in premature infants born to preeclamptic mothers.
Methods: Premature infants who were admitted to Uludag University, School of Medicine, Neonatal Intensive Care Unit between June 2006 and December 2007 were included in this study.