Publications by authors named "Zuguang Chen"
Article Synopsis
- Pulmonary arterial hypertension (PAH) is a severe condition associated with high blood pressure in the pulmonary arteries, leading to heart failure and increased death risk; this study explores its connection to genes related to hypoxia and cuproptosis.
- The researchers used genetic data analysis, including single-cell RNA sequencing, to identify key genes linked to PAH and assessed immune cell differences, constructing a robust diagnostic model with a high accuracy rate.
- The study identified several significant diagnostic genes, including specific markers tied to immune cell types, which could facilitate better understanding and diagnosis of PAH in the future.
Cathepsin S (CTSS) and Sirtuin-1 (SIRT1) played crucial roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the associations between the polymorphisms of CTSS as well as SIRT1 and COPD in Asian population remain elusive. In the present study, one single nucleotide polymorphism (SNP) in rs12068264 was discovered (in 385 individuals) to be associated with the susceptibility of COPD in a Chinese Han population.
View Article and Find Full Text PDFTo evaluate the association between severe pulmonary embolism events and bevacizumab, we conducted the first meta-analysis evaluating the incidence and risk of pulmonary embolism associated with bevacizumab-based therapy. We searched PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov up to September 2016 for randomized controlled trials comparing bevacizumab with no bevacizumab on cancer patients.
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