Publications by authors named "Zugen Cheng"
Article Synopsis
- - The study investigates the harmful effects of microplastics (MPs) on young rats' bone development, revealing that exposure to MPs led to decreased growth, shorter bone length, and altered calcium and phosphorus levels.
- - Using various methods, including administering ER stress inhibitors and agonists, researchers found that MPs induced significant changes in the growth plate structure and increased the expression of genes associated with ER stress, which negatively impacted chondrocyte health.
- - The findings suggest that microplastics can cause growth retardation and bone damage in developing organisms, primarily through mechanisms related to endoplasmic reticulum stress and disrupted bone formation processes.
Article Synopsis
- Obesity is a major public health concern linked to heart problems, particularly subclinical myocardial injury, which increases heart failure risk; this study investigates mechanisms behind this issue.
- Mice were fed a high-fat diet to create an obesity model, and researchers measured various health indicators and assessed inflammation and macrophage behavior related to heart injury.
- The study found that reducing LEAP-2 levels improved heart health in obese mice by reducing inflammation and promoting a beneficial macrophage type (M2), suggesting that targeting LEAP-2 might be a strategy to mitigate obesity-related heart damage.
Introduction: Obesity has been believed to be closely linked with many kinds of diseases including atherosclerosis, hypertension, cerebrovascular thrombosis, and diabetes. Ghrelin and Homeobox transcript antisense RNA (HOTAIR) were believed to be involved in the regulation of myocardial injury.
Methods: The obesity mice model was established through feeding mice (C57BL/6J, male, eight-week-old) with high-fat diet and palmitate (PA)-induced cardiomyocyte injury.
Purpose: To evaluate the effects of anatase and rutile TiO nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.
Methods: Three-week-old male rats were orally administered anatase TiO NPs and rutile TiO NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated.