Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes.

Background: Inadequate glycemic control in patients with type 2 diabetes (T2DM) is a major public health problem and a significant risk factor for the progression of diabetic complications.

Aim: To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin (HbA1c) ≥ 10% and varying backgrounds of glycemic control.

Methods: This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.

Seroprevalence of bovine leukemia virus in cattle and buffaloes in the border provinces of the Eastern Anatolia region, Türkiye: insights into the eradication of infection.

Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, an oncogenic deltaretrovirus that has emerged as a potential zoonotic infection. The BLV naturally infects cattle and causes economic losses through a slow persistent infection with various clinical symtoms following preleukosis. The main objective of this study was to determine the seroprevalence of BLV antibodies in cattle and buffaloes in the border provinces of the Eastern Anatolia region, Türkiye, using the agar gel immunodiffusion (AGID) assay and enzyme-linked immunosorbent assay (ELISA).

Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.

Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the immunopathology associated with each phenotype. Although defective T and B cell development is common to all phenotypes, patients with hypomorphic variants can generate T and B cells with signatures of immune dysregulation and produce autoantibodies to a broad range of self-antigens, including type I interferons.

Comparative Analysis of Cosmetic and Functional Outcomes in Corneal Tattooing (Keratopigmentation) versus Ocular Prosthesis.

Objectives: This study compares the cosmetic and functional outcomes of corneal tattooing/keratopigmentation and ocular prostheses in rehabilitating disfigured eyes, focusing on esthetic appearance and emotional well-being.

Methods: Ninety-two patients were included: 48 received corneal tattooing, and 44 were fitted with ocular prostheses. Anophthalmic surgery was indicated for trauma, painful blind eye, endophthalmitis, tumor, and corneal ulcer, while corneal tattooing was performed for trauma, corneal ulcer, and endophthalmitis.

Effects of Transcranial and Trans-Spinal Direct Current Stimulation Combined with Robot-Assisted Gait Training on Gait and Fatigue in Patients with Multiple Sclerosis: A Double-Blind, Randomized, Sham-Controlled Study.

Multiple Sclerosis (MS) is a chronic neurological condition that impairs motor and sensory functions, particularly gait. Non-invasive neuromodulation techniques aim to enhance functional recovery and motor-cognitive outcomes, though their effectiveness remains debated. This study compared the effects of transcranial direct current stimulation (tDCS) and trans-spinal direct current stimulation (tsDCS), combined with robotic-assisted gait training (RAGT), on motor function and fatigue in people with MS (pwMS).

Is Kinesio taping an alternative to static wrist orthosis in patients with carpal tunnel syndrome? A randomized clinical trial.

Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. Conservative treatments are effective for treating mild and moderate CTS. There is still a need for studies to investigate the superiority of conservative treatments over each other.

Fast tracking of Hg ions in living cells, food, and environmental samples using a new mitochondria-targeted red emitting probe and its portable applications.

Mercury is one of the most hazardous heavy metals and is capable of biomagnification, thereby posing severe risks to ecosystems and human health. Therefore, selective, sensitive, and rapid detection of Hg in a wide range of samples is essential. Herein, we report the synthesis of a new 2-(benzo[d]thiazol-2-yl) phenol-based fluorescent probe (PyS) and its potential as a fluorescent probe for detecting Hg ions in various real samples such as rice, garlic, shrimp, and root samples.

Resource-efficient photonic networks for next-generation AI computing.

Current trends in artificial intelligence toward larger models demand a rethinking of both hardware and algorithms. Photonics-based systems offer high-speed, energy-efficient computing units, provided algorithms are designed to exploit photonics' unique strengths. The recent implementation of cellular automata in photonics demonstrates how a few local interactions can achieve high throughput and precision.

Supramolecular modification of sustainable high-molar-mass polymers for improved processing and performance.

The plastic waste crisis is among humanity's most urgent challenges. However, widespread adoption of sustainable plastics is hindered by their often inadequate processing characteristics and performance. Here, we introduce a bio-inspired strategy for the modification of a representative high molar mass, biodegradable aliphatic polyester that helps overcome these limitations and remains effective at molar masses far greater than the entanglement molar mass.

Knowledge and attitudes of preclinical and clinical medical students toward epilepsy: A cross-sectional study from Turkey.

Objective: The aim of this study is to evaluate the epilepsy-related knowledge and attitudes toward epilepsy in medical students. In addition, these parameters were evaluated according to national geographic regions, preclinical and clinical characteristics.

Methods: This study was a cross-sectional, observational design and it was conducted among medical students in a centrally located city, Turkey.

European clinical practice guideline: managing and treating laryngopharyngeal reflux disease.

Objective: To propose a European consensus for managing and treating laryngopharyngeal reflux disease (LPRD) to guide primary care and specialist physicians.

Methods: Twenty-three European experts (otolaryngologists, gastroenterologists, surgeons) participated in a modified Delphi process to revise 38 statements about the definition, clinical management, and treatment of LPRD. Three voting rounds were conducted on a 5-point scale and a consensus was defined a priori as agreement by 80% of the experts.

Effect of Maternal Probiotics on Infantile Colic Symptoms and Maternal Quality of Life and Maternal Attachment: A Single-Blind, Randomized Controlled Study.

Background: Infantile colic (IC) is a functional gastrointestinal disorder characterized by crying spells lasting more than 3 hours a day, more than 3 days a week, for 3 weeks, according to the Rule of Three's.

Objective: This study aimed to evaluate the effect of added probiotic supplementation in the mother's diet on the crying frequency of babies with infantile colic, maternal attachment, and maternal quality of life.

Design And Settings: 36 mothers and their babies were randomized into two groups.

Comparison of clinical results between transpulmonary thermodilution monitoring and conventional methods in cardiac surgery: An observational study.

The Pulse Index Contour Continuous Cardiac Output (PICCO) module provides advanced and continuous monitoring of cardiac output through the use of arterial pulse contour analysis and transpulmonary thermodilution. The objective of this study was to compare the early postoperative outcomes of patients who were monitored using the conventional method and the pulse contour analysis method. A prospective observational study was conducted involving 45 patients who underwent cardiac surgery between 2020 and 2022.

Development and Validation of a Novel Gas-Washing Bottle Incubation System (GBIS) for Monitoring Microbial Growth in Liquid Media Under Well-Controlled Modified Atmosphere Conditions.

The transition towards more sustainable packaging calls for improving our ability to predict, control, and inhibit microbial growth. Despite the importance of modified atmosphere packaging (MAP) in food preservation, the exact relations between MAP gases (CO, O, N) and microbial behavior are still poorly understood. Addressing this major knowledge gap requires a specific infrastructure to gain precise control over the gas composition during storage time.

Skin autonomous antibody production regulates host-microbiota interactions.

The microbiota colonizes each barrier site and broadly controls host physiology. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection. The unique strategies employed at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive.

Association of Low Serum Maresin-1 Levels with Hepatocellular Carcinoma in Cirrhotic Liver.

Background: Maresin-1 (MaR1) is a macrophage-derived antiinflammatory lipid mediator that negatively regulates oxidative and proinflammatory cytokines and also restores integrity in various tissues after inflammation. Non-resolving inflammation is known to have an important role in the pathogenesis of hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the role of MaR1 in pathogenesis and early diagnosis of HCC.

From attributes to communities: a novel approach in social network generation.

Generating networks with attributes would be useful in computer game development by enabling dynamic social interactions, adaptive storylines, realistic economic systems, ecosystem modelling, urban development, strategic planning, and adaptive learning systems. To this end, we propose the Attribute-based Realistic Community and Associate NEtwork (ARCANE) algorithm to generate node-attributed networks with functional communities. We have designed a numerical node attribute-edge relationship computation system to handle the edge generation phase of our network generator, which is a different method from our predecessors.

The Effect of Graded Motor Imagery on Pain and Function in Individuals with Knee Osteoarthritis: A Comparative Randomized Controlled Trial.

Objective: To examine whether graded motor imagery (GMI) was as effective as transcutaneous electrical nerve stimulation (TENS) in improving pain and functionality in patients with knee osteoarthritis (PwKOA).

Design: Forty-six PwKOA were randomized (1:1) into the GMI and the TENS groups. Both groups participated in home-based and functional exercises.

Multidisciplinary Approach to Perihilar and Intrahepatic Cholangiocarcinoma: A Single-Center Experience.

Background/aims: Treatment of perihilar cholangiocarcinoma (PHCC) and intrahepatic cholangiocarcinoma (IHCC) is a challenging issue. We aimed to investigate the clinical characteristics of both tumors and the outcome of our treatment policy.

Material And Methods: We retrospectively analyzed data of 117 patients who were diagnosed with PHCC or IHCC between January 2007 and September 2023.