Nanoparticle Engineering of Aprepitant Using Nano-by-Design (NbD) Approach.

The aim of this research was to develop a nanosuspension of aprepitant (APT) using the Nano-by-Design approach. A novel microfluidization technology was used for processing the formulation. A 3 full factorial design was used for the optimization of dependent variables, which included critical quality attributes like particle size and polydispersity index.