Publications by authors named "Zuberbier T"
Urban Greening and Pollen Allergy: Balancing Health and Environmental Sustainability.
J Allergy Clin Immunol Pract
December 2024
Urban living requires a careful balance between human health and environmental sustainability when selecting urban vegetation. Public gardens and green roofs offer significant environmental benefits, including air filtration, exposure to health-associated microbiota, and mitigation of the urban heat island effect. However, prioritizing allergy-friendly species is crucial to prevent the exacerbation of pollen allergies.
View Article and Find Full Text PDFBackground And Aims: Remnants of laundry detergent ingredients are suspected to be in constant contact with the skin. Allergy sufferers need assurance that the chemicals in everyday products do not cause such disruption. The purpose of this study was to evaluate the effects and tolerability of common laundry detergents on the skin microbiome in individuals with atopic dermatitis.
View Article and Find Full Text PDFObjective: The evaluation of health benefits and harms of an intervention with GRADE Evidence to Decision (EtD) frameworks includes judgments if the effects are "trivial", "small", "moderate" or "large". Such judgments ideally require the a priori establishment of decision thresholds (DTs), whose empirical derivation for single outcomes has been previously described. In this article, we provide a methodological approach to estimate DTs for composite endpoints based on disutilities.
View Article and Find Full Text PDFBackground: Anaphylaxis is a systemic allergic reaction that is potentially life-threatening. Occupational anaphylaxis is an anaphylaxis that occurs in an occupational context. In this position paper, we propose diagnostic criteria for occupational anaphylaxis and provide an overview of the current state of knowledge in terms of prevalence, triggers, prevention, and management.
View Article and Find Full Text PDFArticle Synopsis
- Targeted therapies using biologics for atopic diseases, urticaria, and angioedema are advancing quickly, with several new antibodies developed, tested, and approved for clinical use, like omalizumab and dupilumab.
- There is ongoing research into combining different biologics for enhanced treatment efficacy, expanding their applications to conditions like food allergies and eosinophilic esophagitis.
- There are emerging concerns about unexpected side effects and hypersensitivity reactions associated with these therapies, raising important questions about their safety and mechanisms, particularly in specific patient groups like children.
Background: Intranasal antihistamines (INAH), corticosteroids (INCS), and their fixed combinations (INAH+INCS) are one of the cornerstones of the treatment of allergic rhinitis (AR). We performed a systematic review and network-meta-analysis comparing the efficacy and safety of INAH, INCS, and INAH+INCS in patients with AR.
Methods: We searched four electronic bibliographic databases and three clinical trial databases for randomised controlled trials assessing the use of INAH, INCS, and INAH+INCS in adults with seasonal or perennial AR.
Background: The exact cause of hidradenitis suppurativa (HS) remains unclear, although emerging research suggests a link between infectious agents and inflammatory skin diseases. The association between human papillomavirus (HPV) infection and HS development, however, has not been studied.
Objective: The objective of this study was to evaluate the risk of incident HS in patients with HPV infection.
Article Synopsis
- IgE-mediated food allergies are the most common type, causing quick and serious reactions that affect patients' and caregivers' lives.
- Omalizumab is a humanized monoclonal antibody that binds to IgE, reducing allergic reactions, and has been approved by the FDA for treating these food allergies.
- The GALEN ANACARE Consensus Statement supports omalizumab's use based on a systematic review and expert agreement, noting it is currently the only drug that can significantly reduce IgE-mediated food allergic reactions, although more evidence is needed for stronger guideline recommendations.
Article Synopsis
- * CREB influences the expression and function of degranulation receptors, notably FcεRI and MRGPRX2, though they are not as dependent on CREB as KIT, which is significantly affected by its inhibition.
- * CREB helps maintain the releasability of mast cells and regulates MRGPRX2 expression in a unique way, highlighting its importance in both the survival and secretory abilities of skin mast cells.
Article Synopsis
- CRUSE® is an app designed for people with chronic spontaneous urticaria (CSU) to track their symptoms using visual analogue scales (VASs), aiming to assess the app's effectiveness in measuring disease activity.
- A study analyzed three VASs related to CSU impact on daily life, including one specifically for the severity of urticaria, one for productivity, and a general health measure (EQ-5D), using data from nearly 6,000 patients over many days.
- The results showed that the CRUSE® app's VASs demonstrate strong validity and reliability, with the "VAS urticaria" being most effective in capturing symptom changes, while the minimal important difference (MID) values indicated meaningful changes
Time to ACT-UP: Update on precautionary allergen labelling (PAL).
World Allergy Organ J
October 2024
Article Synopsis
- Precautionary Allergen Labelling (PAL) is used to warn people about possible allergens in food that could affect those with allergies.
- The World Allergy Organization found that PAL is not consistently regulated, which makes it confusing for people with food allergies.
- There are discussions among global organizations to create better rules for PAL so that it is clear and helpful for everyone, but there are still some challenges to making these rules work everywhere.
Article Synopsis
- - Patient-reported outcome measures (PROMs) are tools that help assess a patient's health at a specific time and are important for personalized healthcare.
- - The paper reviews the use of visual analog scales (VAS) for measuring asthma and allergic rhinitis control, particularly focusing on the MASK-air app, which includes electronic VAS forms.
- - A randomized controlled trial was conducted to validate the electronic VAS, and further evaluations confirmed the effectiveness of VAS questions and additional medication scores for allergic asthma symptoms.
Article Synopsis
- Researchers explored how large language models (LLMs) can aid in generating guideline questions for allergic rhinitis by using online search data and direct LLM interactions.
- They identified 3975 unique search queries, distilling them to 37 relevant questions, with 6 new questions prioritized for the 2024 ARIA guidelines that were not initially considered by the expert panel.
- The study suggests that LLMs can complement traditional methods in developing clinical guideline questions, although the findings are limited to a single case study.
Intranasal Versus Oral Treatments for Allergic Rhinitis: A Systematic Review With Meta-Analysis.
J Allergy Clin Immunol Pract
December 2024
Background: Treatments for allergic rhinitis include intranasal or oral medications.
Objective: To perform a systematic review with meta-analysis comparing the effectiveness of intranasal corticosteroids or antihistamines versus oral antihistamines or leukotriene receptor antagonists in improving allergic rhinitis symptoms and quality of life.
Methods: We searched four bibliographic databases and three clinical trial datasets for randomized controlled trials (1) assessing patients aged 12 years and older with seasonal or perennial allergic rhinitis, and (2) comparing intranasal corticosteroids or antihistamines versus oral antihistamines or leukotriene receptor antagonists.
Chronic spontaneous urticaria (CSU) is a skin disease caused by mast cells that produce inflammatory mediators. Immune checkpoint receptors such as program death-1 (PD-1) and T-cell immunoglobulin and mucin domain 3 (TIM-3) are essential for the pathophysiology of many autoimmune and allergic diseases. The aim of this study was to investigate the expression of PD-1 and TIM-3 in CSU patients and their relationship to the anti-inflammatory cytokines (TGF-β and IL-10).
View Article and Find Full Text PDFBackground: Allergic rhinitis (AR) has a substantial socioeconomic impact associated with impaired work productivity.
Objective: To study the impact of AR on work productivity and estimate the corresponding indirect costs for 40 countries.
Methods: We conducted a cross-sectional study using direct patient data from the MASK-air app on users with self-reported AR.
There is insufficient evidence regarding the comparative efficacy and safety of pharmacological treatments of allergic rhinitis (AR). In the context of informing the 2024 revision of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines, we plan to perform three systematic reviews of randomized controlled trials (RCTs) comparing the desirable and undesirable effects (i) between intranasal and oral medications for AR; (ii) between combinations of intranasal and oral medications versus nasal or oral medications alone; and (iii) among different intranasal specific medications. We will search four electronic bibliographic databases and three clinical trials databases for RCTs examining patients ≥ 12 years old with seasonal or perennial AR.
View Article and Find Full Text PDFChronic spontaneous urticaria (CSU) is a debilitating, inflammatory skin condition characterized by infiltrating immune cells. Available treatments are limited to improving the signs and symptoms. There is an unmet need to develop therapies that target disease-driving pathways upstream of mast cell activation to inhibit or delay the progression of CSU and associated comorbidities.
View Article and Find Full Text PDFArticle Synopsis
- * Current treatment guidelines suggest increasing doses of second-generation antihistamines, but many patients don't see improvement due to various underlying causes.
- * New research is shifting toward personalized treatments based on individual patient factors, with promising developments like targeted therapies and medications that may effectively modify the disease.
Article Synopsis
- - The traditional healthcare approach often overlooks patients' personal experiences and strengths, focusing mainly on disease treatment. Person-centered care aims to align medical decisions with individual values and preferences, particularly for those with chronic conditions.
- - This paper seeks to enhance care for rhinitis and asthma by developing digital care pathways and incorporating real-world evidence to create a more patient-centered approach.
- - Key components of the review include advancements in mHealth, the integration of artificial intelligence, a novel classification system for airway diseases, and proposals for the ARIA 2024 guidelines, all targeting a sustainable and applicable healthcare model.
Article Synopsis
- The EADV Task Forces analyzed the Health-Related Quality of Life (HRQoL) measurement in urticaria treatment, highlighting the Dermatology Life Quality Index as the most commonly used tool in clinical trials.
- Many trials lacked specific numeric results on HRQoL changes, complicating comparisons and conclusions across studies.
- The study suggests favoring HRQoL instruments that include minimal clinically significant difference (MCID) data for better relevance in clinical practice rather than just relying on statistically significant changes.
Heat application is known to activate transient receptor potential (TRP) channels, which play a crucial role in sensory perception, including itch. In this study, the effect of a 5-s, 49°C heat application on itch intensity in atopic dermatitis (AD) patients was evaluated. The study comprised 2 parts: a controlled trial investigating the impact of brief heat treatment on mechanically induced itch, and a real-life study of AD patients experiencing itch attacks.
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