Metabolically healthy across body mass index categories in relation to serum Klotho levels: a population-based study.

Background: Metabolic health status and body mass index (BMI) are both key predictors of aging-related diseases and premature mortality. However, the relationship between metabolically distinct phenotypes, classified by BMI categories, and serum Klotho levels-a biomarker of aging-remains poorly understood. This study aimed to investigate the association between metabolically healthy phenotypes and serum Klotho levels among middle and aged adults.

Triple regulation of oxidative-acetylation cycling pathways in COPD glucocorticoid resistance by HuaTanJiangQi capsules.

Glucocorticoid (GC) resistance in chronic obstructive pulmonary disease (COPD) induced by long-term smoking, significantly reduces the quality of life of patients. The complex interaction between antioxidants and acetylation is an important factor that contributes to the slow progression of treatment. This study highlights the development of GC resistance in COPD through 4-hydroxynonenal (4-HNE), multidrug resistance-associated protein 1 (MRP1), histone deacetylase 2 (HDAC2), and nuclear related factor 2 (Nrf2), using enzyme-linked immunosorbent assays, western blotting, and siRNA silencing.

The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases.

Neutrophil extracellular traps (NETs) are unique fibrous structures released by neutrophils in response to various pathogens, exhibiting both anti-inflammatory and proinflammatory effects. In autoimmune conditions, NETs serve as crucial self-antigens triggering inflammatory cascades by activating the inflammasome and complement systems, disrupting self-tolerance mechanisms and accelerating autoimmune responses. Furthermore, NETs play a pivotal role in modulating immune cell activation, affecting adaptive immune responses.

Stable plastid transformation in kiwifruit ().

Unlabelled: Plastid transformation offers valuable benefits in plant biotechnology, such as high-level transgene expression and the absence of gene silencing. Here we describe the first protocol of a plastid transformation system for a woody vine (liana) kiwifruit (). The transgenic DNA carries a spectinomycin-resistance gene () cassette and a green fluorescent protein () reporter gene cassette, flanked by two adjacent kiwifruit plastid genome sequences, thereby allowing targeted insertion between the and genes.

Accurate volume image reconstruction for digital breast tomosynthesis with directional-gradient and pixel sparsity regularization.

Purpose: We aim to develop accurate volumetric quantitative imaging of iodinated contrast agent (ICA) in contrast-enhanced digital breast tomosynthesis (DBT).

Approach: The two main components of the approach are the use of a dual-energy DBT (DE-DBT) scan and the development of an optimization-based algorithm that can yield accurate images with isotropic resolution. The image reconstruction algorithm exploits sparsity in the subject's directional derivative magnitudes, and it also performs direct sparsity regularization to help confine the reconstruction to the true support of the subject.

Electrospun MXene/polyimide nanofiber composite separator for enhancing thermal stability and ion transport of lithium-ion batteries.

Safety of lithium-ion batteries (LIBs) has garnered significant attention. As an essential component of batteries, the separator plays a crucial role in separating the positive and negative electrodes, preventing short circuits, and allowing ion transport. Therefore, it is necessary to develop a high-performance separator that is both thermally stable and capable of rapid Li transport.

Using machine learning models for cuffless blood pressure estimation with ballistocardiogram and impedance plethysmogram.

Introduction: Blood pressure (BP) serves as a crucial parameter in the management of three prevalent chronic diseases, hypertension, cardiovascular diseases, and cerebrovascular diseases. However, the conventional sphygmomanometer, utilizing a cuff, is unsuitable for the approach of mobile health (mHealth).

Methods: Cuffless blood pressure measurement, which eliminates the need for a cuff, is considered a promising avenue.

The six whole mitochondrial genomes for the species: features, evolution and phylogeny.

In this study, the complete mitogenomes of three species ( ZM79-3, ZM33-4 and sp. ZM41-5) were sequenced, assembled and compared with the other three previously sequenced mitogenomes ( VNIIKR SE Dcaul3, MSPL 10-6 and VNIIKR SE Dps12). The six mitogenomes were found to be circular DNA molecules, with lengths ranging from 53,646 bp to 108,865 bp.

Rare Emphysematous Osteomyelitis of the Femoral Head: A Case Report and Literature Review.

Emphysematous osteomyelitis (EO) is a perilous infection of the femoral head. In this case, we present a 66-year-old male patient of Han ethnicity, who had lumbar disc herniation and type 2 diabetes mellitus. The patient reported severe pain in his lower back and right lower limb, which had worsened over the past 20 days.

Lower limb biomechanical differences between forehand and backhand forward lunges in amateur female badminton players.

Background: Forehand and backhand forward lunges are frequently performed in badminton, placing significant demands on the lower limbs. The purpose of this study was to examine the differences in lower limb biomechanics between these two lunge types in female amateur players.

Methods: This study involved 17 female amateur badminton players performing forehand and backhand forward lunges.

Intensive stress impedes hair follicle growth through triggering cell cycle arrest of hair follicle stem cells.

The detrimental effects of stress on hair growth are supported by empirical and experimental evidence, but the specific impact and mechanisms remain poorly understood. Here we utilized two intensive stress paradigms, repeated resiniferatoxin (RTX) injections and physical restraint in mice, to assess the effects of intensive stress on hair follicle growth after depilation. Initially, macroscopic pictures of the mice dorsal skin and HE staining showed a substantial inhibition of depilation-induced hair growth in both telogen and anagen hair follicle growth under intensive stress induced by RTX and restraint.

Designing interfacially stable Na-ion polymer electrolytes with tailored local solvation structures.

Azodicarbonamide (ADA) is selected as an additive to the polymer electrolyte (PE) to improve the stability of the NaFeMnNiO cathode. ADA can capture hydrogen from the polymer and induce local structures, enhancing the ionic conductivity of the PE. Moreover, the dehydrogenated ADA can bond to Fe ions, preventing the PE from decomposing.

Cell-Derived Basal Membrane-Like Extracellular Matrix Promotes Endothelial Cell Expansion and Functionalization.

Engineering cellular microenvironments with biomaterials is an effective strategy for endothelial cell expansion and functionality in vascular tissue engineering. The basement membrane (BM) is a natural vascular endothelium microenvironment that plays an important role in promoting rapid expansion and function of endothelial cells. However, mimicking the crucial function of BM with an ideal biomaterial remains challenging.

[The combined regimen based on obinutuzumab plus glucocorticoid for 4 cases of relapsed iTTP].

To evaluate the efficacy and safety of obinutuzumab combined with glucocorticoid-based therapy in patients with relapsed immune thrombotic thrombocytopenic purpura (iTTP). This study analyzed the efficacy and adverse reactions of four patients with relapsed iTTP who were treated with a combination of obinutuzumab and glucocorticoids to assess the effectiveness and safety of the treatment. All four patients had a history of multiple relapses and had previously undergone treatment with rituximab and bortezomib.

[Safety and efficacy of mitoxantrone liposome combined chemotherapy in the treatment of mixed phenotype acute leukemia].

To evaluate the safety and efficacy of mitoxantrone liposome (MIT-LIP) combined chemotherapy in treating mixed phenotype acute leukemia (MPAL) . December 2021 to November 2024, MPAL patients who underwent the MAED (MIT-LIP + cytarabine + etoposide + dexamethasone) regimen were retrospectively analyzed. Data on clinical characteristics, adverse reactions, therapeutic outcomes, and long-term prognoses were collected.

[Clinical characteristics and prognostic analysis of newly diagnosed acute myeloid leukemia with critical illness].

This study retrospectively analyzed the clinical characteristics of patients newly diagnosed with acute myeloid leukemia (AML) who were admitted to the hematology intensive care unit (HCU) with critical illness. It also examined factors associated with critical illness and early mortality in these patients. Clinical data were collected from 91 newly diagnosed AML patients admitted to the HCU of the Department of Hematology, First Affiliated Hospital of Soochow University, from October 2020 to 2024.

[Strengthen the construction of hematological intensive care unit to comprehensively improve the prognosis of patients with hematological critical illnesses].

The survival time of patients with hematological malignancies has improved significantly in recent years; however, the incidence of severe complications has also increased and may escalate rapidly alongside the progression of the primary disease. The establishment of a hematology intensive care unit (HCU) is of great clinical significance for early identification, centralized monitoring and management of hematological critically ill patients, leveraging the advantages of specialties, accurately controlling the condition, and improving the level of diagnosis and treatment in hematology. It is recommended that blood centers with adequate resources actively establish HCUs to enhance the prognosis of patients with hematological critical illnesses.

Synthesis of 1-Aminoisoquinolines via Rh(III)-Catalyzed C-H Cascade Annulation of Benzamidines with Iodonium Ylides.

A Rh(III)-catalyzed C-H cascade annulation reaction of benzamidine hydrochlorides with iodonium ylides has been successfully accomplished, providing an efficient strategy for the synthesis of various 1-aminoisoquinoline derivatives in moderate to good yields. Here, iodonium ylide serves as an accessible and safe carbene precursor. Further derivatizations were implemented to demonstrate the potential utility of this cascade annulation reaction.

Deciphering Interfacial Stability of Sulfide and Halide-Based Electrolytes via Operando X-ray Photoelectron Spectroscopy.

Combined solid electrolytes address cathode-anode compatibility in all-solid-state Li-ion batteries (ASSLBs), yet interface stability and ion transport mechanisms between different electrolytes remain unclear. Herein, we investigate LiPSCl (LPSC), LiInCl (LIC), and LiZrOCl (LZOC) composite electrolytes through electrochemical analysis and operando X-ray photoelectron spectroscopy. Our results reveal that the electrostatic potential difference between LPSC and LIC inhibits Li migration, leading to the decomposition of LIC into InCl and LiCl, causing battery failure.

Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway.

BTB and CNC homology 1 (Bach1) is a transcription factor that mediates oxidative stress and inflammation and participates in the progression of diseases such as atherosclerosis, colitis, and acute lung injury. In this study, we aimed to explore the role of Bach1 in radiation pneumonitis (RP) and elucidate its underlying mechanism. Bach1 expression was significantly elevated in the lung tissues of RP mice.

Use of Sodium-Glucose Transport Protein 2 Inhibitors and the Incidence of Urolithiasis: A Multi-Database and Cross-Country Study in Patients With Type 2 Diabetes Mellitus.

The benefits of sodium-glucose transport protein 2 inhibitor (SGLT2i) use on severe urolithiasis requiring surgery remains unclear. All patients with incident T2D in Taiwan National Health Institution databases (2016-2021) and TriNetX datasets (2014-2023) were retrospectively analyzed. The study analyzed a propensity score-matched pairs with T2D treated with SGLT2i or dipeptidyl peptidase 4 inhibitors (DPP4i).

Skin-Inspired and Self-Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy.

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by the structure and function of the skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed of hydrophobic methyl acrylate (MA) and (3-acrylamidophenyl)boronic acid (AAPBA) network and co-loaded with antioxidant quercetin (Q) and antibiotic levofloxacin (L) for efficient diabetic wound therapy. The hydrophobic MA segments undergo phase separation to form a dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, and high water content.

Comparison of surgical outcomes between single-layer and double-layer pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis.

Introduction: Postoperative pancreatic fistula (POPF) is the most severe complication after pancreaticoduodenectomy (PD), and this study investigates the effects of single-layer and double-layer pancreaticojejunostomy (PJ) on POPF.

Evidence Acquisition: Four electronic databases were systematically searched until March 2024: PubMed, Web of Science, Embase, and Cochrane Library. Statistical analysis was performed using Review Manager (RevMan) software.

High-Temperature-Induced Fused Polycyclic Aromatic Multiple Resonance Emitters Exhibiting Narrowband and Pronounced Red-Shifted Emission.

Synthetic methodology is a fundamental framework for preparing functional materials, significantly advancing their development. Herein, a novel 6π electrocyclization reaction is unexpectedly discovered that promotes further ring closure in materials derived from multi-resonance thermally activated delayed fluorescence (MR-TADF) compounds, known for their narrow emission. By simply raising the reaction temperature, this process significantly red-shifts the emission peak of the target material while effectively narrowing its emissive width and greatly enhancing its optoelectronic performance.