Publications by authors named "Zu-lu Gao"

Article Synopsis
  • - The study aimed to assess the infection status in children aged 3-6 years in Jiangxi Province in 2014, to help inform prevention and control measures for parasitic diseases.
  • - A survey involving 1,486 children found an overall infection rate of 13.73%, with variations based on age and income levels, peaking at 18.24% in 5-year-olds.
  • - The results indicate a significant infection problem among children in the province, prompting the need for ongoing monitoring and control efforts by health authorities.
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Objective: To explore the cut-off value of the indirect haemagglutination test (IHA) method for schistosomiasis japonica diagnosis in different endemic areas.

Methods: Totally 55 nature villages of the lake-type endemic counties, Yugan and Xinzi, in Poyang Lake Region of Jiangxi Province were chosen as the study fields, and all the villagers over 5 years old were parallelly examined by Kato-Katz method + miracidial hatching test and IHA method. The detection data were analyzed by the correlation analysis, and the threshold values of the IHA method in different endemic areas were decided by the receiver operating characteristic (ROC) curve.

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Objective: To evaluate the situation of realizing schistosomiasis transmission control in Jiangxi Province.

Methods: The situation of reaching the criteria of schistosomiasis transmission control was evaluated by using the method of field surveys combined with retrospective investigations.

Results: The schistosome infection in human was kept at a stable low level, and the infection rate in residents was below 1% in 90.

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Objective: To investigate the spray of niclosamide ethanolamine salt on prevention of bovine schistosomiasis in the field so as to provide a technical support for the improvement of schistosomiasis control strategy.

Methods: A total of 160 buffalo were selected as experimental objects marked by ear-mark numbers. All the buffalo were administered with praziquantel and then randomly divided into 3 groups, which were sprayed with niclosamide ethanolamine salt (500 ml per head) every 15 d (Group A), every 30 d (Group B) and an agent without niclosamide ethanolamine salt every 15 d (Group C as the control), respectively.

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Article Synopsis
  • The study aimed to analyze the immune response of patients with schistosomiasis japonica in a low endemic area, focusing on specific immune cell types and cytokine levels.
  • Patients classified as positive for schistosomiasis showed significantly higher levels of CD4+CD25+T regulatory cells compared to negative controls, indicating an immune response shift.
  • Post-treatment results revealed increased levels of IFN-gamma (an immune-activating cytokine) and decreased levels of IL-10 (an immune-suppressing cytokine), suggesting that the presence of CD4+CD25+Tregs may dampen cellular immunity following infection.
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Article Synopsis
  • The study aimed to analyze the antibody responses to Schistosoma japonicum in patients from the Poyang Lake region, focusing on both soluble egg antigen (SEA) and adult worm antigen (AWA).
  • It found that patients who tested positive for eggs had significantly higher levels of specific antibody isotypes compared to those who tested negative and a control group from a non-endemic area.
  • Post-treatment, most antibody levels decreased significantly within twelve months, indicating a reduction in immune response over time.
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Objective: To understand the rates of underestimation of Schistosoma japonicum infection by Kato-Katz technique with different stool samples and different smears in field site.

Methods: With 27 Kato-Katz thick smears (3 stool samples with 9 thick smears each) for 3 consecutive years as a "gold standard", the rates of underestimation of schistosome infection by Kato-Katz technique with different stool samples and different smears were evaluated in a schistosomiasis endemic village.

Results: The examined rates of schistosome infection increased and the rates of underestimation decreased gradually with the increase of the number of Kato-Katz thick smears examined.

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Objective: To explore the correlation of the ultrasound indices of liver and spleen in schistosomiasis japonica and with infection frequency, infection time and EPG.

Methods: The canonical correlation was applied to analyze the correlation of the hepatosplenic ultrasound indices in schistosomiasis japonica, and the correlation of the ultrasound indices with infection frequency, infection time and EPG. The proportions of variation related to each other in liver and spleen were analyzed by the redundancy analysis.

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Objective: To explore the synthetical index for diagnosing schistosomiasis with ultrasound and to assess the prevalence rate with the index.

Methods: Ultrasound indexes of schistosomiasis Japonicum were analyzed by principal component analysis, and the synthetical indexes were assessed by ROC curve.

Results: Among the abnormal rates of the 6 indexes, the lowest was 1.

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