Ginkgolide B inhibits lung cancer cells promotion via beclin-1-dependent autophagy.

Background: Ginkgolide B (GKB) is a major active component of the extracts of Ginkgo biloba leaves, and it has been used as an anti-cancer agent. However, it is unknown whether GKB has the therapeutic effects on lung cancer. Here, we studied the effects of GKB on lung cancer cells.

Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p.

Long noncoding RNAs (lncRNAs) have been reported to be involved in the occurrence and tumorigenesis of numerous malignant cancers. Microarray expression profiles were used to screen colorectal cancer (CRC)-related differentially expressed genes and lncRNAs, which revealed that insulin receptor substrate 1 (IRS1) and lncRNA plasmacytoma variant translocation 1 (PVT1) were highly expressed in CRC. This study aimed to investigate the regulatory role of lncRNA PVT1 in CRC.

Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKα/NF-κB and neuronal apoptotic pathways.

Although naloxone has been documented to exert neuroprotection in animal model of cerebral ischemia, the mechanism is not well understood. In this present study we investigated whether naloxone affected the mitochondrial apoptotic pathway in ischemic brain injury of rats. SD rats were subjected to a permanent middle cerebral artery occlusion surgery, and received naloxone (0.

A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer.

The bispecific antibody is a novel antibody, which can target two different antigens and mediate specific killing effects by selectively redirecting effector cells to the target cells. Here, we designed and synthesized a bispecific antibody (BsAb) that can bind cellular-mesenchymal to epithelial transition factor (c-MET, overexpressed in several human solid tumor), and programmed death-1 (PD-1, involved in cancer cell immune evasion) with high affinity and specificity. We found that BsAb can induce the degradation of c-MET protein in cancer cells, including MKN45, a gastric cancer cell line, and A549, a lung cancer cell line.

[The effect of human PBMC on the growth of oral squamous cell carcinoma cell].

Purpose: To explore the effect and mechanism of activated peripheral blood mononuclear cell (PBM) on the growth and apoptosis of oral squamous carcinoma cells in vitro.

Methods: ELISA, RT-PCR, MTT and flow cytometry were used to detect cytokines secretion and oral squamous carcinoma cell growth and apoptosis affected by activated PBMCs with PHA. The data was analyzed using SPSS17.

[Expression and clinical significance of serum interleukin-27 level in patients with oral squamous cell carcinoma].

Purpose: To explore the clinical significance of serum interleukin-27 (IL-27) level in patients with oral squamous cell carcinoma (OSCC).

Methods: Forty patients pathologically confirmed as OSCC were included, and 20 healthy adults were used as controls. The serum IL-27 were tested with enzyme -linked immunosorbent assay(ELISA).