Publications by authors named "Zu-Tao Yu"
Int J Biol Macromol
August 2023
Article Synopsis
- ABCA1 is crucial for removing cholesterol from macrophages, making it key to understanding and treating atherosclerosis.
- The study discovered a G-quadruplex (G4) structure in the ABCA1 promoter that is essential for its transcription, and stabilizing this G4 with ligands increases ABCA1 expression.
- NONO protein binds to the G4 and regulates ABCA1 levels; the G4 ligand enhances this binding, leading to reduced cholesterol accumulation in macrophages and presenting a potential new approach to preventing atherosclerosis.
