[Dual role of NF-κB and its target gene iNOS in cerebral ischemic tolerance induced by focal ischemic preconditioning].

Objective: To investigate the effect of focal cerebral ischemic preconditioning on the expression of nuclear factor kappa B (NF-κB) and its target gene inducible nitric oxide synthase (iNOS) and to explore its role in ischemic tolerance in rats.

Methods: A total of 32 SD rats were divided into 4 groups. The control group received sham surgery (SS) twice only.

A novel mutation of the epsilon-sarcoglycan gene in a Chinese family with myoclonus-dystonia syndrome.

In a Chinese myoclonus-dystonia syndrome (MDS) family presented with a phenotype including a typical MDS, cervical dystonia, and writer's cramp, genetic analyses revealed a novel 662 + 1insG heterozygous mutation in exon 5 in the epsilon-sarcoglycan (SGCE) gene, leading to a frameshift with a down stream stop codon. Low SGCE mRNA levels were detected in the mutation carriers by real-time PCR, suggesting that the nonsense mutation might interfere with the stability of SGCE mRNA. This is the first report on Chinese with a SGCE mutation leading to MDS.

[A study on the protective efficacy of magnesium against anoxic damage to cultured neurons of rats].

Objective: This is an in vitro study aimed to assess the influence of magnesium on cultured anoxic cortical neurons of rats.

Methods: After being treated with MgSO4 and Mg(2+)-ATP respectively, the cortical neurons of rats were given mixture of 97.5% N2 and 2.

[Effects of three-stage rehabilitation treatment on acute cerebrovascular diseases: a prospective, randomized, controlled, multicenter study].

Objective: To evaluate the effect of tertiary rehabilitation treatment on acute cerebrovascular diseases.

Methods: Fifteen tertiary rehabilitation networks were set up throughout the country. 1078 patients with acute cerebrovascular diseases were randomly divided into 2 groups: rehabilitation group and control group, out of which 19 patients died, 157 dropped out, and 7 successive evaluations were completed in 902 patients that.