Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism.

Background: Telomerase plays an essential role in cancer cell proliferation. In this study, we investigated inhibition mechanism of aloe emodin (AE) on three different types of breast cancer cell lines, MDA-MB-453, MDA-MB-231 and MCF-7.

Methods: The cells were treated with different concentrations of AE.