JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.

Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury. Bromodomain-containing protein 4 (BRD4) is an important Bromo and Extra-Terminal (BET) protein to participate in inflammatory responses. However, it is still unknown about the specific connection between BRD4 and inflammation-related pyroptosis in endotoxemia colon.

Emodin resists to Cyprinid herpesvirus 3 replication via the pathways of Nrf2/Keap1-ARE and NF-κB in the ornamental koi carp (Cyprinus carpio haematopterus).

Cyprinid herpesvirus 3 (CyHV-3) causes high mortality in carp. Emodin has been shown of the effects of antioxidant, anti-inflammatory and antiviral. In present study, we investigated the preventive effects and mechanism of emodin on CyHV-3 infection.

Selective CO Photoreduction into C Product Enabled by Charge-Polarized Metal Pair Sites.

Selective CO photoreduction into a high-energy-density C product is still challenging. Here, charge-polarized metal pair sites are designed to trigger C-C coupling through manipulating asymmetric charge distribution on the reduction intermediates. Taking the synthetic partially reduced CoO nanosheets as an example, theoretical calculations unveil the asymmetric charge distribution on surface cobalt sites.

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells.

Background: Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases, but under orchitis, the role and underlying molecular mechanism of MEG3 in Leydig cells remain unclear.

Methods: Lipofectamine 2000 was used for the cell transfections.

Clinicopathological and prognostic significance of osteopontin expression in patients with prostate cancer: a systematic review and meta-analysis.

Background: Evaluation of the feasibility for osteopontin (OPN) to serve as a biomarker in the prognosis and clinical-pathological features of prostate cancer (PCA) patients.

Methods: The original publications related to OPN and PCA were comprehensively searched in the online databases, including PubMed, Embase, Cochrane Library, Web of Science, Medline, Wanfang and China National Knowledge Infrastructure up to August 2019. Results were analyzed by Revman 5.

2,6-DMBQ suppresses cell proliferation and migration via inhibiting mTOR/AKT and p38 MAPK signaling pathways in NSCLC cells.

2,6-Dimethoxy-1,4-benzoquinone (2,6-DMBQ) is the major bioactive compound found in fermented wheat germ extract. Although fermented wheat germ extract has been reported to show anti-proliferative and anti-metabolic effects in various cancers, the anticancer potential and molecular mechanisms exerted by 2,6-DMBQ have not been investigated in non-small cell lung cancer (NSCLC) cells. Here, we report that 2,6-DMBQ suppresses NSCLC cell growth and migration through inhibiting activation of AKT and p38 MAPK.

Hemicolectomy Does Not Provide Survival Benefit for Right-Sided Mucinous Colon Adenocarcinoma.

Background: The extent of bowel resection is widely debated in colon cancer surgery. Right hemicolectomy (RHC) and partial colectomy (PC) are the most common operation options for right-sided colon cancer (RCC). However, there are still no treatment guidelines or published studies to guide surgical options for mucinous adenocarcinoma (MAC) of RCC.

Fabrication of Au Nanoparticle Arrays on Flexible Substrate for Tunable Localized Surface Plasmon Resonance.

In this work, Au nanoparticle (AuNP) arrays on shape memory polyurethane (SMPU) substrates serve as flexible materials for tunable localized surface plasmon resonance (LSPR). AuNP arrays prepared by diblock copolymer self-assembly are transferred from rigid silicon wafers onto flexible SMPU substrates with ultrasonic treatment rather than peeling off directly. The resultant AuNP array SMPU films have excellent mechanical properties and stable thermodynamic properties.

Development of a double-layer EPS-ASM2d model to illustrate the effect on mainstream biological phosphorus system in side-stream phosphorus recovery process.

In order to deeply investigate the influences of side-stream phosphorus (P) recovery operation on mainstream biological P removal system, an improved activated sludge model no. 2 (ASM2d) was established to illuminate the metabolic processes of P in a side-stream P recovery reactor. The improved ASM2d (named D-EPS-ASM2d) was established by extending of the P metabolic processes of double-layer extracellular polymeric substances (EPS) into conventional ASM2d model.

Study on the treatment of sudden cadmium pollution in surface water by a polymer enhanced ultrafiltration process.

The removal of cadmium(ii) pollution in surface water by a polymer enhanced ultrafiltration (PEUF) process was investigated. Three water soluble polymers, chitosan (CTS), polyvinyl alcohol (PVA) and polyacrylate sodium (PAAS), were selected for this study. Of the three polymers, PAAS had strong interactions with Cd, and the PEUF achieved a high removal of Cd; therefore, PAAS was used as a complexing agent for the simulated cadmium pollution experiment.

HOReID: Deep High-Order Mapping Enhances Pose Alignment for Person Re-Identification.

Despite the remarkable progress in recent years, person Re-Identification (ReID) approaches frequently fail in cases where the semantic body parts are misaligned between the detected human boxes. To mitigate such cases, we propose a novel High-Order ReID (HOReID) framework that enables semantic pose alignment by aggregating the fine-grained part details of multilevel feature maps. The HOReID adopts a high-order mapping of multilevel feature similarities in order to emphasize the differences of the similarities between aligned and misaligned part pairs in two person images.

Identification of Genome Sequences of Polyphosphate-Accumulating Organisms by Machine Learning.

In the field of sewage treatment, the identification of polyphosphate-accumulating organisms (PAOs) usually relies on biological experiments. However, biological experiments are not only complicated and time-consuming, but also costly. In recent years, machine learning has been widely used in many fields, but it is seldom used in the water treatment.

Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.

Siglec15 is an emerging target for normalization cancer immunotherapy. However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of Siglec15 in bladder cancer (BLCA) remains elusive. We comprehensively evaluated the expression pattern and immunological role of Siglec15 using pan-cancer analysis based on RNA sequencing data obtained from The Cancer Genome Atlas.

Identification of key genes and microRNA regulatory network in development and progression of urothelial bladder carcinoma.

Background: Bladder cancer as other cancers contains multiple dynamic alterations in progression. Theoretically, large number of genes participates in cancer progression. In the present study, the interconnections of genesets defined by Gene Set Enrichment Analysis (GSEA) and tumor histopathological stages were characterized.

Clinicopathological characteristics and survival outcomes for testicular choriocarcinoma: a population-based study.

Background: Due to the scarcity of cases of testicular choriocarcinoma (CC), its clinicopathological characteristics and prognosis have not been well summarized. Consequently, we conducted this population-based case-control study to characterize the features of testicular CC.

Methods: The SEER database was used to extract qualified data.

Smoking status and pathological response to neoadjuvant chemotherapy among patients with bladder cancer: a pooled analysis.

Background: Smoking status has been confirmed as an independent prognostic factor for bladder cancer. However, for patients who received neoadjuvant chemotherapy (NAC), the influence of smoking status on the pathological response and prognosis remains unclear. This pooled analysis aimed to investigate whether smoking status is an independent risk factor for pathological response, recurrence, and prognosis in patients with bladder cancer who undergo NAC.

Adjuvant chemotherapy in patients with locally advanced bladder cancer after neoadjuvant chemotherapy and radical cystectomy: a systematic review and pooled analysis.

Background: Neoadjuvant chemotherapy (NAC) could ameliorate the stage of locally advanced bladder cancer (LABC) which is defined in pT3/T4 and/or pN+, improve overall survival (OS) before radical cystectomy (RC). However, for LABC, the decision to use adjuvant chemotherapy (AC) after NAC and RC is still controversial.

Methods: We performed a comprehensive search of the PubMed, Embase, and Cochrane Library databases for literature that reported prognosis after using AC following NAC and RC.

LncRNA SNHG9 is a prognostic biomarker and correlated with immune infiltrates in prostate cancer.

Background: Expression of Long non-coding RNA (LncRNA) small nucleolar RNA host gene 9 (SNHG9) is observed in some cancer types, while its role in prostate cancer (PCa) is unclear. We aimed to demonstrate the relationship between SNHG9 and PCa based on The Cancer Genome Atlas (TCGA) database.

Methods: Kruskal-Wallis test, Wilcoxon signed-rank test, and logistic regression were used to evaluate relationships between clinical-pathologic features and SNHG9 expression.

Melamine Foam Derived 2H/1T MoS as Flexible Interlayer with Efficient Polysulfides Trapping and Fast Li Diffusion to Stabilize Li-S Batteries.

Lithium-sulfur (Li-S) batteries featuring high-energy densities are identified as a hopeful energy storage system but are strongly impeded by shuttle effect and sluggish redox chemistry of sulfur cathodes. Herein, annealed melamine foam loaded 2H/1T MoS (CF@2H/1T MoS) is prepared as a multifunctional interlayer to inhibit the shuttle effect, improve redox kinetics, and reduce the charge-discharge polarization of Li-S batteries. The CF@2H/1T MoS becomes fragmented structures after assembling the cell, which not only benefits to adsorb and catalyze LiPSs but also to significantly buffer the volume expansion due to a large number of gaps between fragmented structures.

Theoretical Combined Experimental Study of Unique He Behaviors in High-Entropy Alloys.

Exploring new structural materials with strong He damage tolerance is one of the key tasks for the development of nuclear reactors. Helium (He), one of the most common elements in the nuclear environment, often forms undesired bubbles in metallic materials and may result in void swelling as well as high-temperature intergranular embrittlement. In this study, the behaviors of He in high-entropy alloy (HEA) TiZrHfMoNb and its constituents are systematically investigated both theoretically and experimentally.

Depression and perceived stress among the medical residents under the unified doubletrack training systems.

Objectives: It is an important reform for medical education in China to combine professional postgraduate training with standardized resident training. This study aims to evaluate the depression and perceived stress in postgraduate students of clinical medicine and residents from society and to determine the relation between depression and perceived stress in medical residents.

Methods: Chinese Perceived Stress Scale (CPSS) and Self-Rating Depression Scale (SDS) were applied to 330 residents (including 235 postgraduate students of clinical medicine and 95 residents from society) from a Class-A Grade-3 genernal hospital in Hunan Province to evaluate and compare the depression and perceived stress in postgraduate students of clinical medicine and residents from society.

Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC-MS/MS and its application to a pharmacokinetic study.

XiaoJin Capsule (XJC) is a classic Traditional Chinese Medicine formula for clinical treatment of thyroid nodules, mammary gland hyperplasia and breast cancer. For the specification and rational application of XJC in the future, an accurate and specific LC-MS/MS method was developed and validated for quantitative determination of five components in rat plasma after oral administration of XJC. The collected plasma samples were extracted by protein precipitation with methanol-acetonitrile (1:3, v/v) mixture solvent and separated on a C column using a gradient elution system.

CD4 T cell exhaustion leads to adoptive transfer therapy failure which can be prevented by immune checkpoint blockade.

Cytotoxic CD8 T cell exhaustion is one of the mechanisms underlying the tumor immune escape. The paradigm-shifting immune checkpoint therapy can mitigate CD8 T lymphocyte exhaustion, reinvigorate the anticancer immunity, and achieve durable tumor regression for some patients. Emerging evidence indicates that CD4 T lymphocytes also have a critical role in anticancer immunity, either by directly applying cytotoxicity toward cancer cells or as a helper to augment CD8 T cell cytotoxicity.

Compressive Behavior of (CuZrAl)Dy Bulk Metallic Glass at Different Strain Rates.

The mechanical properties of (CuZrAl)Dy bulk metallic glass (BMG) were characterized under various strain rates by quasi-static and dynamic compressive tests. In the quasi-static compressive tests, the yield stress of (CuZrAl)Dy BMG increased from 1234 MPa to 1844 MPa when the strain rate was increased from 0.001 s to 0.

circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/β-catenin feedback loop promotes bladder cancer progression.

Bladder cancer (BC) is one of the most commonly diagnosed cancers globally. Recently, circular RNAs (circRNAs) have been revealed to participate in BC progression with diverse mechanisms. However, mechanisms of circ_100984 in BC have not been determined.