Topical Vitamin D Receptor Antagonist/Partial-Agonist Treatment Induces Epidermal Hyperproliferation via RARγ Signaling Pathways.

Vitamin D and A derivatives are well-known endogenous substances responsible for skin homeostasis. In this study we topically treated shaved mouse skin with a vitamin D agonist (MC903) or vitamin D antagonist/partial agonist (ZK159222) and compared the changes with acetone (control treatment) treatment for 14 days. Topical treatment with ZK159222 resulted in increased expression of genes involved in retinoic acid synthesis, increased retinoic acid concentrations and increased expression of retinoid target genes.

[Liquid-based cervical cytology ThinPrep screening in Hungary].

Introduction: Liquid-based cervical cytology has been developed as an alternative for conventional Papanicolaou cervical cytology.

Aim: The aim of this study was to determine the quality assurance of liquid-based cervical cytology.

Method: 4573 cervical cytology smears were classified according to the Bethesda (2001) system.