Publications by authors named "Zsuzsanna Orsos"
Article Synopsis
- Polyphenols found in various extracts, such as green tea and coffee, can help reduce cancer risk by affecting gene expressions related to cancer promotion in mice.
- The study focused on the impact of these extracts on specific microRNAs and genes in the liver, spleen, and kidneys after exposure to a carcinogen called DMBA.
- Results showed that while most extracts effectively reduced harmful gene expressions, the Chinese bayberry and polyphenol extracts had less impact on certain microRNAs, indicating some specificity in their chemopreventive actions.
Specific gene and miRNA expression patterns are potential early biomarkers of harmful environmental carcinogen exposures. The aim of our research was to develop an assay panel by using several miRNAs for the rapid screening of potential carcinogens. The expression changes of miR-124-1, miR-212, miR-132, miR-134, and miR-155 were examined in the spleen, liver, and kidneys of CBA/Ca mice, following the 20 mg/bwkg intraperitoneal 7,12-dimethylbenz(a)anthracene (DMBA) treatment.
View Article and Find Full Text PDFWe studied the effect of allelic polymorphisms of cytochrome P450 1A1 (CYP1A1) and uridine-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) on the risk of development of head and neck cancers and overall survival. One hundred and forty-two head and neck cancer patients (48 with laryngeal, 42 with hypopharyngeal and 52 with mesopharyngeal tumours) were included in the study. The control group (150 individuals) included volunteers without malignant tumours.
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- Adult stem cells are crucial for repairing damaged organs, and this study explores using a dietary supplement, Olimpiq StemXCell, to boost stem cell production for better organ regeneration instead of relying on cytokine injections.
- In three experiments involving liver damage, induced diabetes, and cardiac injury in rodents, the animals consuming StemXCell showed significant improvements in organ recovery compared to control groups.
- The findings suggest that dietary strategies may effectively enhance stem cell production and aid in the healing of damaged organs, highlighting a potential alternative to traditional cytokine treatments.
Background: Aspartame (L-phenylalanine N-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene.
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