Publications by authors named "Zsolt Tamas Papp"
NMDA receptors in the prefrontal cortex (PFC) play a crucial role in cognitive functions. Previous research has indicated that angiotensin II (Ang II) affects learning and memory. This study aimed to examine how Ang II impacts NMDA receptor activity in layer V pyramidal cells of the rat PFC.
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- Three types of small RNA therapeutics—siRNAs, miRNAs, and ASOs—have advantages over traditional drugs by targeting gene products, offering new treatment avenues for various diseases.
- While these small RNAs are valuable in preclinical research for gene silencing and drug target validation, off-target effects, particularly miRNA-like ones, can complicate results and lead to adverse effects.
- The review discusses strategies such as sequence design and AI-based predictions to minimize these off-target effects, providing a comprehensive overview of current computational methods and experimental validation techniques to support small RNA therapy development.
The development of opioid tolerance in patients on long-term opioid analgesic treatment is an unsolved matter in clinical practice thus far. Dose escalation is required to restore analgesic efficacy, but at the price of side effects. Intensive research is ongoing to elucidate the underlying mechanisms of opioid analgesic tolerance in the hope of maintaining opioid analgesic efficacy.
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