Quantitative investigation of bone microvascularization from 3D synchrotron micro-computed tomography in a rat model.

A new method for simultaneous 3D imaging and analysis of microvascularization and bone microstructure in rat bone is developed. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-microCT) coupled to an automatic image analysis procedure. Analysis of bone microvascularization is generally performed from 2D histology.