Publications by authors named "Zsolt Lang"

: Children with CP show deficits in executive function compared to their typically developing peers, based on the majority of the available evidence. However, the magnitude of these deficits, as well as the proportions of the shortfalls in the three main components, have not yet been examined. This is the first meta-analysis to synthesize evidence on the magnitude of differences between patients with cerebral palsy (CP) and typically developing populations in different components of executive function skills (working memory, inhibitory control and cognitive flexibility), and thus makes recommendations on which areas of executive functioning are in greatest need of intervention.

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  • - Metacarpophalangeal joint pain is a frequent issue causing lameness in racehorses, often linked to radiological changes in the sagittal ridge (SR) of the third metacarpal bone, affecting their performance and sales value.
  • - A study examined 40 yearlings using computed tomography (CT) at three intervals to assess the SR, revealing that the average Hounsfield Unit (HU) values increased over the first six months but stabilized afterward, and many observed lesions were found to reduce in size.
  • - Hypoattenuating lesions were common, especially in the dorsal aspect of the SR, but notably, these lesions did not correlate with lameness in the horses throughout the training
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The prevalence of an infectious disease of animals living in separate groups (e.g. herds) is naturally analyzed using a Bayesian hierarchical latent class model.

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Males of many insects, including butterflies, produce mate-guarding devices, such as mating plugs, to prolong guarding and prevent future female matings in the male's absence. In a few butterflies, large external mate-guarding devices, that is, sphragides, occur. Gór et al.

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In this work we exploited the parallel dense tick and hedgehog populations of an urban park in Budapest, Hungary as a good host-parasite model to obtain detailed data about this physiological relationship. Over a 27-week period from April to October, 57 hedgehogs were captured in an urban park and kept for 10-14 days in animal house. All dropped off ticks were sampled, which allowed us to draw more a detailed picture of -hedgehog relationships.

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Objectives: The benefit of using gelatin solution in cardiac surgery is still controversial. Previous data suggested adverse interactions of gelatin infusion with acute kidney injury (AKI) or coagulopathy. The purpose of this study was to evaluate the association between perioperative gelatin use and fluid overload (FO), hemodynamic stability, and outcomes compared to crystalloid-based fluid management.

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  • Recent oncology guidelines suggest BRCA1/2 testing for prostate cancer patients, and PARP inhibitors are available for those with mutation-positive metastatic castration-resistant prostate cancer (mCRPC) after prior treatment.
  • A meta-analysis was conducted to compare the effectiveness of abiraterone, enzalutamide, and docetaxel on PSA response, progression-free survival (PFS), and overall survival (OS) in BRCA1/2 positive mCRPC patients, synthesizing data from 16 studies.
  • The results showed enzalutamide had a better PFS compared to abiraterone, while all three treatments were effective; however, further studies directly comparing these treatments are needed for conclusive results.
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The authors analysed epidemiological data of the Hungarian tick-borne encephalitis epidemic from the past seven decades. A total of 911 meningitis serosa cases were described from 1930-1950 s by local hospital physicians, indicating that the virus had been present in the country decades before its official identification in 1952. The virus spread freely in the 1950s-1960s, occupying almost all habitats where ticks occurred in large numbers.

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Background: A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis. Although several common factors play a role in their development and platelets are damaged in both diseases, the combined relationship of the three conditions was never investigated previously.

Methods: A prospective, real-life observational cohort study was conducted with the inclusion of 108 CRC patients and 166 voluntary non-CRC subjects.

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Objective: The goal of this study was to compare factor concentrate (FC)-based and blood product-based hemostasis management of coagulopathy in cardiac surgical patients in terms of postoperative bleeding, required blood products, and outcome.

Design: Retrospective, propensity score-matched analysis.

Setting: Single, tertiary, academic medical center.

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The hypothesis that the inter-individual parameter variability is an unexploited area of ecotoxicology was proposed several decades ago. Although some illustrative examples were presented to support this hypothesis in the last decades, it has never been tested on an extensive, coherent database. In this study, variance changes of 105 dose-response curves were analysed.

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  • Paratuberculosis (PTBC) is a chronic disease affecting dairy cows, caused by Mycobacterium avium subsp. paratuberculosis (MAP), which poses productivity challenges in dairy herds globally.
  • A study analyzed data from five dairy herds in Hungary, focusing on the differences in milk production, reproductive parameters, and culling between MAP ELISA positive and negative cows.
  • Results showed ELISA positive cows produced significantly less milk, had higher somatic cell counts, experienced delays in conception and longer calving intervals, and were culled earlier compared to their negative counterparts.
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Objective: The aim of our study was to determine the associations of heifer reproductive performance with survival up to the first calving, first-lactation milk yield, and the probability of being culled within 50 days after first calving.

Methods: Data from 33 large Holstein-Friesian commercial dairy herds were gathered from the official milk recording database in Hungary. The data of heifers first inseminated between January 1, 2011 and December 31, 2014 were analyzed retrospectively, using Cox proportional hazards models, competing risks models, multivariate linear and logistic mixed-effects models.

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The aim of this study was to analyze the impact of reproductive management practices on fertility in primiparous and multiparous dairy cows and to identify the differences by parity. Data on reproductive performance and management of cows were gathered from 34 large commercial Holstein-Friesian dairy herds in Hungary. Individual data on 23 781 cows that calved in the studied herds in 2014 were collected from the national milk recording database and used to calculate the reproductive indices.

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Insecticide exposure may cause both transgenerational and multigenerational effects on populations, but the molecular mechanisms of these changes remain largely unclear. Many studies have focused on either transgenerational or multigenerational mechanisms but did neglect the comparative aspects. This study assessed whether the pyrethroid insecticide etofenprox (formulation Trebon 30 EC) shows transgenerational and/or multigenerational effects on the survival and reproduction of Folsomia candida (Collembola).

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Body size is one of the most fundamental characteristics of all organisms. It influences physiology, morphology, behavior, and even interspecific interactions such as those between parasites and their hosts. Host body size influences the magnitude and variability of parasite size according to Harrison's rule (HR: positive relationship between host and parasite body sizes) and Poulin's Increasing Variance Hypothesis (PIVH: positive relationship between host body size and the variability of parasite body size).

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A study was performed to survey the virological prevalence of bovine viral diarrhoea (BVD) virus (BVDV) in cattle herds in Hungary between 2008 and 2012. A total of 40,413 samples for BVDV detection and 24,547 samples for antibody testing were collected from 3,247 herds (570,524 animals), thus representing approximately 75% of the cattle population in Hungary. Retrospective Bayesian analysis demonstrated that (1) the herd-level true virus prevalence was 12.

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This study assessed persistence and compliance with anti-osteoporosis therapies, and associations between compliance and clinical outcomes (fracture, fracture-related hospitalization and death), in Hungarian women with postmenopausal osteoporosis. The study used the Hungarian National Health Insurance Fund Administration database and included women with PMO aged at least 50 years, for whom a prescription for anti-osteoporosis medication had been filled between 1 January 2004 and 31 December 2013 (index event). Persistence (prescription refilled within 8 weeks of the end of the previous supply) was evaluated over 2 years; good compliance (medication possession ratio ≥ 80 %) was evaluated at 1 year.

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Background: Affective temperaments can be considered the subclinical manifestations of affective disorders, which have a bidirectional relationship with cardiovascular diseases.

Objectives: Aim of this study was to assess the role of affective temperaments in primary hypertension, which is the leading risk factor of cardiovascular morbidity and mortality.

Methods: In total, 251 consecutive patients, including 179 patients being treated for primary hypertension with anti-hypertensives, with chronic disorders without diagnosed depression were enrolled in a primary care setting.

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Prevalence of a disease is usually assessed by diagnostic tests that may produce false results. Rogan and Gladen (1978) described a method to estimate the true prevalence correcting for sensitivity and specificity of the diagnostic procedure, and Reiczigel et al. (2010) provided exact confidence intervals for the true prevalence assuming sensitivity and specificity were known.

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We conducted a nationwide, full-population based investigation to evaluate the comparative effectiveness of all marketed second generation antipsychotic drugs (SGA) prescribed for outpatients with the diagnosis of schizophrenia in Hungary. Using the national central register, our observational follow-up study included all patients with schizophrenia or related disorder between 01/01/2006 and 30/06/2008. The study cohort comprised 9567 patients who started new SGA during the inclusion period (01/07/2007-30/06/2008).

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Aims: The study was designed to test the clinical application of the grading of lid-parallel conjunctival folds (LIPCOF) as a diagnostic test for dry eye.

Methods: At 12 centres in 11 countries, 272 eyes of 272 dry eye patients (75 men, 197 women) were examined. Their mean age was 52.

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Purpose: To investigate the post-blink changes of the topographical regularity indices, the corneal wavefront aberrations and the tear lipid layer's interference pattern, and analyze the relationship between these parameters' changes.

Methods: Sequential topographical measurements were recorded on 23 normal participants. The surface regularity index (SRI), surface asymmetry index (SAI), corneal total higher order aberrations (HOA) root mean square (RMS), Coma RMS and Spherical RMS were calculated from the topographical measurement.

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Subcutaneous dirofilariosis caused by Dirofilaria repens is common in dogs and it is an emerging helminthozoonosis in Europe, Asia, Africa and also in Hungary. Macrocyclic lactones are used for preventing the infection; however, their activity against the microfilariae and mature stages of this species is questionable. Selamectin is widely used for the prophylaxis of heartworm (D.

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Authors performed standardized, respiratory and risk factor questionnaire surveys among the adult population of two towns of Hungary: the first in Nyergesújfalu, according to the distance of the flat from asbestos cement factory, and the second in Komárom, a settlement of a smaller burden of industry. They excluded the data of former asbestos industry workers from the calculations. By the analysis of the Nyergesújfalu data they concluded that odds of chronic obstructive pulmonary disease (COPD) symptoms, other illnesses and tumors were not significantly higher among the inhabitants living in the vicinity of the asbestos factory than those living farther from there, based on raw and adjusted comparisons.

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