Estimating the Bias of Model Compounds for the Determination of Species-Specific Protonation Constants.

The previously unknown extent of the goodness of using model compounds for the microspeciation of polyprotic systems was studied. Mirror-symmetric dibasic compounds and their monosubstituted derivatives were investigated to quantify how the derivatives are appropriate models of the minor microspecies to be mimicked in various microspeciation systems. The results were analyzed using statistical methods.