Publications by authors named "Zsofia Richter"
Article Synopsis
- Temporal lobe epilepsy (TLE) is a common type of epilepsy in adults that is hard to treat with medication.
- The study looked at brain tissue from TLE patients and found more connections (called synapses) and neurons in the white matter compared to non-epileptic patients.
- The results suggest that these extra neurons might play a role in how seizures happen and could be involved in the brain circuits that cause epilepsy.
The aim of the present work was to characterize neurons in the archi- and neocortical white matter, and to investigate their distribution in mesial temporal sclerosis. Immunohistochemistry and quantification of neurons were performed on surgically resected tissue sections of patients with therapy-resistant temporal lobe epilepsy. Temporal lobe tissues of patients with tumor but without epilepsy and that from autopsy were used as controls.
View Article and Find Full Text PDFA loss of calbindin immunoreactivity in granule cells of the hippocampal dentate gyrus is a characteristic feature of temporal lobe epilepsy with hippocampal sclerosis. Whether decreased calbindin expression is unique to the hippocampal sclerosis associated with cryptogenic temporal lobe epilepsy, or also occurs in tumor- or malformation-related epilepsy, is unknown. We show that calbindin immunoreactivity in granule cells has been decreased in epilepsy regardless of its etiology.
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