[What is behind a wound?- case report].

Chronic wound is a wound that does not heal in four to eight weeks. The most important predisposing factors are tissue ischemia and infection. In approximately 80% of cases, chronic wounds of lower limbs are the final form of chronic venous insufficiency.

Differences between keratoacanthoma and squamous cell carcinoma using TGF-alpha.

Squamous cell carcinoma (SCC) and keratoacanthoma (KA) are skin neoplasms of epithelial origin. In contrast to clearly malignant skin neoplasm SCC, KA is an unusual cutaneous neoplasm with a tendency to regression. The distinction between these two neoplasms, on histological grounds only, is still a challenge.

[Burn injuries: what have we learned from history].

Severe burn injuries present a significant public health risk and are often associated with a life-threatening systemic inflammatory response. With the traditional approach, patients often stay in hospital longer and are more prone to problems like joint contractures, hypertrophic scars and infections due to delayed healing. The approach to burn injuries has been improving through and has been adopting new technologies and materials.

Psoriasis vulgaris - an inflammatory skin disease and/or benign epidermal hyperplasia.

Psoriasis vulgaris (PV) is a systemic inflammatory disease in which immune and genetic factors are involved in the pathogenesis. Some treatment approaches in PV patients have been similar to therapy of some tumors. This fact has led to a new scientific approach to PV not only as an inflammatory disease, but also as a benign epidermal hyperplasia or a benign tumor.

Effect of progesterone and pregnancy on the development of varicose veins.

The aim of this study was to investigate the contribution of progesterone in the development of primary varicose veins on lower limbs during pregnancy. In 50 primiparae with varicose veins, serum progesterone level was quantitatively determined in the 14th week of pregnancy and results were compared with those obtained in a control group of 25 primiparae without visible varicose veins. The mean serum progesterone concentration recorded in pregnant women with dilated veins (159.

Correlation between clinical-dermatoscopic and histopathologic diagnosis of skin tumors in our patients.

In this study 103 patients with skin tumors were examined. Among them there were 43 (42%) male patients and 60 (58%) female patients. Working diagnosis was obtained by clinical examination using dermoscope.

Phytophotodermatitis in Rijeka region, Croatia.

Contact with plants can cause phototoxic or rarely photoallergic reactions. Phototoxic dermatitis (photophytodermatitis) occurs after contact or ingestion of plants containing furocumarins i.e.

Molecular and genetic mechanisms in melanoma.

Recent studies have indicated an increasing incidence of melanoma worldwide. Although UV signature mutations are found rarely in melanoma cells, there is some evidence that intense intermittent exposure to sunlight can induce melanocyte tumorigenesis, and this is also observed after UV irradiation in some animals. The purpose of this paper is to review some of the most important mechanisms involved in the pathogenesis of this tumor.

Influence of PUVA and UVB radiation on expression of ICAM-1 and VCAM-1 molecules in psoriasis vulgaris.

The expression of adhesion molecules Intercellular adhesion molecule-1 (ICAM-1) and Vascular cell adhesion molecule-1 (VCAM-1) is increased in lesional and in non-lesional skin of psoriatic patients, and play role in pathogenesis of the disease. PUVA and UVB therapy are important treatments of psoriasis vulgaris. It has been demonstrated that UVA and UVB therapies reduce expression of these molecules.

Giovanni Battista Cambieri and the beginning of venereology in Rijeka region.

In 1790, an infectious disease appeared in the village of Skrljevo near Rijeka, and spread to the nearby villages and then to Istria, Slovenia and other parts of Croatia. In 1800, the nature of the disease was first investigated by the protomedicus Massich, who believed it was a combination of syphilis and scabies. After him, the protomedicus of the region G.