[Changes in function of sarcoplasmic reticulum and myocardial phospholipid content in immune heart damage].

The effect of acute cytotoxic reaction in the heart on Ca transport activity in the sarcoplasmic reticulum and the phospholipid content of the myocardium was studied. A single intracoronary injection of anticardiac serum reduced Ca, Mg-ATPase activity and the Ca energy-dependent transport but caused no changes in membrane permeability to Ca. As the result of immune damage the content of phospholipids--cardiolipin and phosphatidylethanolamine--in the myocardium reduced.

[The correlations between changes in coronary vascular tonus and eicosanoid formation during an immune action on the heart].

Activation of the lipoxygenase way of the arachidone acid metabolism was shown to play a major role in development of pathological processes in the heart. The data on interrelationship between the formation of eucosanoids and the character of the heart immune response to inhibition of lipoxygenase, were obtained. A correlation was found between the increase in the LTS4 in the blood and the development of prolonged constrictor responses of the coronary vessels.