Successful use of mepolizumab for severe hypereosinophilic vasculitis with c-ANCA positivity in a previously healthy 7-year-old boy.

An unusual case of a pediatric patient with severe eosinophilic vasculitis causing digital ischemia is reported. The patient responded well to the anti-IL-5 agent mepolizumab, lending support for use of mepolizumab in pediatric patients with hypereosinophilic syndromes.

Knowledge, Attitudes, and Practices of Allergists/Immunologists Regarding Transition of Care for Primary Immunodeficiency Patients.

Purpose: Only some allergists/immunologists provide care throughout the lifespan despite their training. Although transition of care (TOC) guidelines exist, research on provider perspectives on TOC for pediatric primary immunodeficiency (PID) patients is lacking. We aimed to characterize knowledge, attitudes, and practices and establish clinician needs using a needs assessment survey.

Second hand smoke exposure in children: environmental factors, physiological effects, and interventions within pediatrics.

Background: Second hand smoke (SHS) exposure has long been correlated with many adverse disease processes, particularly in children. For children growing up with socioeconomic disadvantages and increased exposure to SHS, exposure can have far-reaching consequences.

Objective: The purpose of this review was to examine the literature assessing the effects of SHS exposure in children, as well as the perspectives of both parents and providers regarding current practices in cessation counseling.