Publications by authors named "Zouhair Mostaphaoui"
Article Synopsis
- A growing number of poorly water-soluble new chemical entities are being discovered in drug development, prompting the use of polymeric micelles made from block copolymers for better delivery of these lipophilic drugs.
- Researchers established a screening method to synthesize seven different block copolymers (BP001 to BP007), varying in composition, surface properties, and lipophilicity, and characterized them using H(1)-NMR and SEC methods.
- The study found that micelles, primarily composed of BP006 and BP007, had a suitable size and strong drug-polymer interactions, leading to enhanced performance and controlled release of dexamethasone, with a half-life of 11 hours in human plasma.
