Publications by authors named "Zouboulis K"
Article Synopsis
- Recent advancements in hidradenitis suppurativa (HS) research have faced challenges due to rapid therapeutic development and lack of outcome measures, leading to the halt of some studies.
- The HS 3D-SeboSkin model, which combines human skin and sebocytes, has been utilized to study the effects of adalimumab, an approved biologic that targets inflammatory cells and promotes healing in HS lesions.
- Adalimumab shows varying effects on cellular proteins in patients, reducing several inflammatory markers while failing to alter abnormal cell differentiation, highlighting the need for personalized approaches in treatment development.
Article Synopsis
- Chronic inflammation and issues with hair follicle cell differentiation are key factors in the development of hidradenitis suppurativa (HS), with obesity and metabolic syndrome also being significant risk factors.
- A systematic review examined the molecular mechanisms behind HS, identifying biomarkers and potential repurposing of existing drugs, including adalimumab, which is already approved for this condition.
- The study confirmed the interconnected nature of HS with other comorbidities like inflammatory bowel disease and arthritis, highlighting the importance of molecular research for better understanding and treatment of HS.
Our previous study on nitroxides in o-terphenyl (OTP) revealed two separable decoherence processes at low temperatures, best captured by the sum of two stretched exponentials (SSE) model. Dynamical decoupling (DD) extends both associated dephasing times linearly for 1 to 5 refocusing pulses [Soetbeer et al., Phys.
View Article and Find Full Text PDFApocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.
J Eur Acad Dermatol Venereol
July 2020
Background: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS).
Objective: Detection of apocrine gland involvement in HS.
Methods: Apocrine glands were isolated from skin biopsies of involved and uninvolved skin of HS patients (n = 16, females : males 1 : 1) by laser capture microscopy and studied by whole transcriptome profiling.
Background: The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease-driving mechanisms and tissue targeting.
Objective: Robust characterization of the underlying HS mechanisms and detection of the involved skin compartments.
Methods: Hidradenitis suppurativa/acne inversa molecular taxonomy and key signalling pathways were studied by whole transcriptome profiling.
In the analysis of polymers by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), a commonly observed ionization pathway is cation-adduct formation, as polymers often lack easily ionizable (basic/acidic) functional groups. The mechanism of this process has been hypothesized to involve gas-phase cation attachment. In previous experiments, a split sample plate set-up has been introduced, enabling separate deposition of the components on individual MALDI plates.
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