Comprehensive Analysis of Anticoagulant Therapy in Patients with Isolated Atrial Flutter.

Limited comparative data exist regarding the risk of cardiogenic emboli in patients with isolated atrial flutter (AFL). Some studies suggest a lower complication risk in AFL compared to atrial fibrillation (AFib), but methodological limitations and conflicting reports necessitate a comprehensive investigation. Our analysis proposes that isolated AFL carries a lower risk of ischemic events and left atrial thrombus formation than AFib.

G-Quadruplex Forming DNA Sequence Context Is Enriched around Points of Somatic Mutations in a Subset of Multiple Myeloma Patients.

Multiple myeloma (MM) is the second most common hematological malignancy, which remains incurable despite recent advances in treatment strategies. Like other forms of cancer, MM is characterized by genomic instability, caused by defects in DNA repair. Along with mutations in DNA repair genes and genotoxic drugs used to treat MM, non-canonical secondary DNA structures (four-stranded G-quadruplex structures) can affect accumulation of somatic mutations and chromosomal abnormalities in the tumor cells of MM patients.

Particleboard Creation from Agricultural Waste Residue of Seed Hemp.

In this research, agricultural residue of seed hemp variety "Adzelvieši" was used to create hemp particleboard samples. Hemp was grown in three experimental fields where it was observed that after seed harvesting, 3.5 tonnes of hemp stems per hectare remained.

Boosted excitation of the fifth cyclotron harmonic based on frequency multiplication in conventional gyrotrons.

We discovered a specific property of the eigenmodes of a cylindrical waveguide, due to which efficient mode excitation at ultrahigh (s=4n+1, n is integer) multiples of the gyrofrequency can be provided by a polyhelical weakly relativistic electron beam, standardly used for gyrotron operation. In the proof-of-principle experiment with a V-band gyrotron driven by a 25-keV, 2-A beam, about 100 mW radiation power at the fifth cyclotron harmonic (0.22 THz) has been detected in the cw regime.

Modulation instability of an electromagnetic wave interacting with a counterpropagating electron beam under condition of cyclotron resonance absorption.

In this paper, transmission of a monochromatic wave through a counterpropagating electron beam under the condition of cyclotron resonance absorption is studied by theoretical analysis and numerical simulation. Conditions of the modulation instability (MI) are analyzed. The MI strongly affects the regimes of transmission.

Entrainment, stopping, and transmission of microwave solitons of self-induced transparency in counter-propagating magnetized electron beam.

Based on numerical simulations of a boundary problem, we study various scenarios of microwave soliton formation in the process of cyclotron resonance interaction of a short electromagnetic pulse with a counter-propagating initially rectilinear electron beam taking into account the relativistic dependence of the cyclotron frequency on the electrons' energy. When a certain threshold in the pulse energy is exceeded, the incident pulse can propagate without damping in the absorbing beam, similar to the effect of self-induced transparency in optics. However, mutual motion of the wave and electrons can lead to some novel effects.

Genome Instability in Multiple Myeloma: Facts and Factors.

Multiple myeloma (MM) is a malignant neoplasm of terminally differentiated immunoglobulin-producing B lymphocytes called plasma cells. MM is the second most common hematologic malignancy, and it poses a heavy economic and social burden because it remains incurable and confers a profound disability to patients. Despite current progress in MM treatment, the disease invariably recurs, even after the transplantation of autologous hematopoietic stem cells (ASCT).

Formation of microwave frequency-chirped solitons of self-induced transparency under conditions of cyclotron resonance absorption.

We study the formation of solitons of microwave self-induced transparency (M/W-SIT) which occurs under cyclotron resonance interaction of an electromagnetic pulse with an initially rectilinear magnetized electron beam. Taking into account the relativistic dependence of the gyrofrequency on the particle energy for electromagnetic wave propagating with a phase velocity different from the speed of light (i.e.

CYP2C9 and VKORC1 genotyping for the quality of long-standing warfarin treatment in Russian patients.

A total of 263 warfarin naive patients with indications to long-term anticoagulation were included in prospective multicenter study and randomized into Pharmacogenetics and Standard dosing groups. The loading warfarin dose in Pharmacogenetics group was calculated by Gage algorithm and corrected starting on day 5 of treatment according to INR. In Standard dosing group warfarin initial dose was 5 mg and starting on day 3 of treatment it was titrated according to INR.

A novel THz-band double-beam gyrotron for high-field DNP-NMR spectroscopy.

We present the first experimental results of the study on a novel second harmonic THz-band double-beam gyrotron. The tube has demonstrated a stable single-mode operation with output parameters that are appropriate for the next-generation 1.2 GHz dynamic nuclear polarization-nuclear magnetic resonance spectroscopy.

Generation of Rogue Waves in Gyrotrons Operating in the Regime of Developed Turbulence.

Within the framework of the average approach and direct 3D PIC (particle-in-cell) simulations, we demonstrate that the gyrotrons operating in the regime of developed turbulence can sporadically emit "giant" spikes with intensities a factor of 100-150 greater than the average radiation power and a factor of 6-9 exceeding the power of the driving electron beams. Together with the statistical features such as a long-tail probability distribution, this allows the interpretation of generated spikes as microwave rogue waves. The mechanism of spikes formation is related to the simultaneous cyclotron interaction of a gyrating electron beam with forward and backward waves near the waveguide cutoff frequency as well as with the longitudinal deceleration of electrons.

Phase-Imposing Initiation of Cherenkov Superradiance Emission by an Ultrashort-Seed Microwave Pulse.

For the first time, we demonstrate experimentally the possibility of Cherenkov superradiant generation with a phase imposed by an ultrashort seed microwave pulse. The phases of seed and initiated Ka-band microwave pulses were correlated with the accuracy of 0.5-0.

Generation of Subterahertz Superradiance Pulses Based on Excitation of a Surface Wave by Relativistic Electron Bunches Moving in Oversized Corrugated Waveguides.

The first experiments on the observation of short pulsed superradiant (SR) emission with the excitation of a surface wave by a relativistic electron bunch moving in an oversized corrugated waveguide were performed. Subterahertz SR pulses with a central frequency of 0.14 THz, an ultrashort duration of 150 ps, and an extremely high peak power of 50-70 MW were generated.

Generation of electromagnetic fields of extremely high intensity by coherent summation of Cherenkov superradiance pulses.

We demonstrate both theoretically and experimentally the possibility of correlating the phase of a Cherenkov superradiance (SR) pulse to the sharp edge of a current pulse, when spontaneous emission of the electron bunch edge serves as the seed for SR processes. By division of the driving voltage pulse across several parallel channels equipped with independent cathodes we can synchronize several SR sources to arrange a two-dimensional array. In the experiments carried out, coherent summation of radiation from four independent 8-mm wavelength band SR generators with peak power 600 MW results in the interference maximum of the directional diagram with an intensity that is equivalent to radiation from a single source with a power of 10 GW.

[Atrial Fibrillation in Patients With Chronic Obstructive Pulmonary Disease Is Associated With Polymorphism of Interleukin 6 Gene].

Unlabelled: It can be suggested that development of atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) is directly related to the system of inflammation. Genetic polymorphism of factors of this system can be one of components of mechanism of AF in COPD. Aim: to elucidate polymorphic markers of genes of factors of the system of inflammation associated with AF in patients with COPD.

Conversion of an electromagnetic wave into a periodic train of solitons under cyclotron resonance interaction with a backward beam of unexcited electron-oscillators.

The possibility of the conversion of intense continuous microwave radiation into a periodic train of short pulses by means of resonant interaction with a beam of unexcited cyclotron electron oscillators moving backward is shown. In such a system there is a certain range of parameters where the incident stationary signal splits into a train of short pulses and each of them can be interpreted as a soliton. It is proposed to use this effect for amplitude modulation of radiation of short wavelength gyrotrons.

[Laboratory monitoring of the efficacy and safety of anticoagulants].

Currently, the pharmaceutical market there are a large number of anticoagulants, each of which has a number of features. An important factor influencing the choice of drug, is whether or not the methodology of fixing its efficacy and safety. The aim of this review is to describe current approaches to the control of the efficacy and safety of anticoagulants.

3D quasioptical theory of terahertz superradiance of an extended electron bunch moving over a corrugated surface.

We consider the superradiance of an extended relativistic electron bunch moving over a periodically corrugated surface for the generation of multimegawatt terahertz pulses. To study the above process we have developed a three-dimensional, self-consistent, quasioptical theory of Cherenkov stimulated emission which includes a description of the formation of an evanescent wave over a corrugated surface and its excitation by rf current induced in the electron bunch.

[Mechanisms of development of thromboembolic complications in patients with atrial fibrillation].

Thomboembolism is the most threatening complication in patients with atrial fibrillation. Main source of embolism is the left atrial thrombosis. Mechanisms of development of thromboembolic complications in patients with arrhythmias are far from being deciphered.

Singly resonant optical parametric oscillator based on adhesive-free-bonded periodically inverted KTiOPO4 plates: terahertz generation by mixing a pair of idler waves.

We implemented a singly resonant optical parametric oscillator based on adhesive-free-bonded periodically inverted KTiOPO4 plates. It has major advantages such as walk-off compensation and oscillation at four wavelengths. The threshold of the oscillation was measured to be 8 MW/cm2, which is about a factor of 4 lower than that based in two separate KTiOPO4 crystals.

High-power terahertz-range planar gyrotrons with transverse energy extraction.

To increase the output power of terahertz gyrotrons to several hundred kilowatts, we suggest using a planar geometry of interaction space with a sheet electron beam and transverse energy extraction. An advantage of this scheme in comparison with conventional cylindrical geometry is the possibility to ensure effective mode selection over the open transverse coordinate in combination with radiation outcoupling that leads to a substantial reduction of Ohmic losses. Similar to unstable resonators in optics for further growth of the radiation power it is beneficial to introduce waveguide tapering.

Investigation of terahertz generation from passively Q-switched dual-frequency laser pulses.

When two Nd:YLF crystals share a Cr:YAG crystal functioning as a single passive Q switch, the timing jitter between each pair of dual-frequency pulses generated by the two crystals has been reduced by a factor of 20. Such a reduction in the timing jitter allows us to generate terahertz pulses by focusing such a passively Q-switched laser beam onto a nonlinear crystal. Such a result represents the first step for us to eventually implement a compact terahertz source based on ultracompact microchip lasers.

[Risk and benefit of oral anticoagulants in atrial fibrillation].

Thromboembolism is the main cause of death and disability of patients with atrial fibrillation. Indirect anticoagulants are effective means of primary and secondary prevention of thromboembolic complications. However in a number of patients risk associated with therapy with indirect anticoagulants might exceed potential benefit.