20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells.

20-Hydroxyecdysone (20E) is an arthropod hormone which is synthesized by some plants as part of their defense mechanism. In humans, 20E has no hormonal activity but possesses a number of beneficial pharmacological properties including anabolic, adaptogenic, hypoglycemic, and antioxidant properties, as well as cardio-, hepato-, and neuroprotective features. Recent studies have shown that 20E may also possess antineoplastic activity.

[PREDICTORS OF RE-BLEEDING IN THE ACUTE PERIOD OF RUPTURE OF CEREBRAL ARTERIAL ANEURYSMS].

to identify predictors of early re-bleeding from AA of the brain and to determine their prognostic value. We carried out a retrospective analysis of 394 case histories of patients aged 18 to 85 years who were treated at the ME "Dnepropetrovsk Regional Hospital named after I. I.

Endovascular treatment of patient with multiple extracranial large vessel stenosis and coexistent unruptured wide-neck intracranial aneurysm using a WEB device and Szabo-technique.

The coexistence of severe extracranial large vessel stenosis and unruptured intracranial aneurysms is not rare. There are different treatment approaches for these conditions, such as initial treatment of the aneurysm before revascularization of the stenosis; single-stage endovascular treatment of both lesions; stenosis eliminating followed by treatment of the aneurysm, or without treating the aneurysm. But, taking into account the risk of aneurysm rupture on the one hand and the risk of ischemic stroke on the other, it is sometimes difficult to choose the right management strategy.

Deep Neural Networks Improve Radiologists' Performance in Breast Cancer Screening.

We present a deep convolutional neural network for breast cancer screening exam classification, trained, and evaluated on over 200000 exams (over 1000000 images). Our network achieves an AUC of 0.895 in predicting the presence of cancer in the breast, when tested on the screening population.

Successful surgical treatment of a patient with combined gunshot shrapnel injuries in the heart and brain complicated by middle cerebral artery pseudoaneurysm.

Successful step-by-step treatment of a combined gunshot shrapnel injury of the brain, damaging the left middle cerebral artery (MCA) branches, and penetrating myocardium injury is discussed. Open brain and heart surgeries were performed. A left MCA pseudoaneurysm was formed postoperatively.

Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study.

Background: Diabetes is a major comorbidity in insomnia patients. The efficacy and safety of prolonged-release melatonin 2 mg in the treatment of glucose, lipid metabolism, and sleep was studied in 36 type 2 diabetic patients with insomnia (11 men, 25 women, age 46-77 years).

Methods: In a randomized, double-blind, crossover study, the subjects were treated for 3 weeks (period 1) with prolonged-release melatonin or placebo, followed by a one-week washout period, and then crossed over for another 3 weeks (period 2) of treatment with the other preparation.

[Effect of sapropel mud on the parameters of oxidative stress and antioxidative defense in acute carbofos poisoning].

Sapropel was tested for its effect on the permeability of erythrocytic membranes and on the erythrocytic and serum levels of ceruloplasmin, malonic dialdehyde, and dienic conjugates in rats after acute poisoning by carbofos, a malathion insecticide. The increased processes of free radical oxidation during carbofos poisoning were suggested by the higher rates of chemiluminescence of erythrocytes and peripheral blood serum. No significant changes in the parameters of blood oxidative stress in the carbofos-poisoned animals during therapeutic-and-prophylactic use of sapropel indicate that the latter has antioxidative properties.

[Surgical treatment of cerebral ischemia caused by multiple occlusions of major cerebral arteries].

The case records of 205 patients with brain ischemia of various degree severity accompanied by two and more main brain arteries occlusion are analyzed. In 176 operated patients 241 revascularizing intervention was conducted. The advantages of surgical method versus conservative one were established.