Publications by authors named "Zorica I Tomasevic"
Background: Thanks to immense improvements in technology over the past few decades, we have witnessed a major shift towards the idea that breast cancer results from a combined effect of multiple common alleles conferring low risk. This study investigates the role of 3 nonsynonymous SNPs in the DNA repair genes XRCC1 (R399Q), RAD51 (G135C) and TP53 (Arg72Pro) in breast cancer in Serbian women.
Patients And Methods: Cases of BRCA1/2-negative hereditary breast cancer (n = 52), sporadic breast cancer (n = 106) and age-matched cancer-free female controls (n = 104) were obtained from the Institute for Oncology and Radiology of Serbia's blood bank.
Article Synopsis
- - Recent advancements in cancer treatment have led to a rise in the use of oral antineoplastic agents, with projections suggesting that 25% of these agents will be administered orally in the near future.
- - While oral medications offer advantages, they also present challenges such as low patient adherence and safety concerns, highlighting the need for better management of patients.
- - Effective patient education is crucial for improving adherence to these therapies, understanding treatment plans, and managing side effects, which can ultimately enhance treatment outcomes and quality of life.
Breast cancer is a complex disease with both genetic and environmental factors involved in its etiology. An important role of polymorphisms in genes involved in DNA repair has been reported related to breast cancer risk. We conducted a case-control study in order to investigate the association of RAD51 135G>C and TP53 Arg72Pro polymorphisms with breast cancer in Serbian women.
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