Irreversible incorporation of L-dopa into the C-terminus of α-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon.

L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias. Despite extensive research on L-dopa-induced dyskinesia, its pathogenesis remains poorly understood.

Experience with the long-term effect of microsurgical penile revascularization.

Fourty-two consecutive men underwent microsurgical penile revascularization for arterial insufficiency at least one year prior to this review. Data on the results of surgery were collected by questionnaire or telephone in 33 men (79%) with complete follow-up and by chart review in 9 men (21%) with partial follow-up. Success was measured as the ability to achieve successful intercourse on the majority of attempts without adjuvant therapy.

Experience with buccal phentolamine mesylate for impotence.

Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papaverine HCl for intracavernous injection. The previous observation by Gwinup, that 50 mg of phentolamine HCl po, 1.

A theoretical model for testis thermoregulation.

Studies going back as far as the early 1920's show that there is a clear relationship between testis temperature and semen quality. The most intriguing question is whether there is a mechanism of thermoregulation which, in the human, maintains testis temperature within certain limits that permit euspermia. Thermoregulation is defined as maintaining some specified (optimum?) temperature plus or minus an error over internal and ambient loss factors.

Progressive systemic sclerosis (scleroderma) and impotence.

Scleroderma, a connective tissue disorder involving multiple organ systems, can be a causal factor in erectile dysfunction. Cases are presented where arteriographic and biopsy evidence supports this. Awareness of this association could make possible an early diagnosis and influence treatment choices.

Measurement of intrascrotal temperature in normal and subfertile men.

Intrascrotal temperatures were measured bilaterally by a non-invasive method in 300 subfertile men (mean sperm count 21.4 x 10(6)/ml) and 30 normospermic control men (mean sperm count 118.7 x 10(6)/ml).

Nonprosthetic surgical strategies for impotence.

The past decade has seen a remarkable expansion of understanding of erection and the treatment of impotence. This has been brought about, in part, by improvements in radiographic techniques for selective pudendal arteriography and dynamic cavernosography, which, in turn, have made possible development of surgical techniques for the management of penile vascular insufficiency and corpus spongiosum venous leakage that yield good short-term results in restoring the capacity for penetration in impotent patients.