[Methodological recommendations for surgical care in patients with hemophilia A receiving prophylactic therapy with emicizumab].

Methodological recommendations for surgical care in patients with hemophilia A receiving prophylactic therapy with emicizumab. Recommendations of the expert group. Moscow, 2024.

[Removal of a dermoid cyst of the floor of the mouth in a patient with severe hemophilia A].

The article presents a case of a surgical treatment of removing a dermoid cyst of the floor of the oral cavity in a patient with severe hemophilia A. A detailed analysis was carried out of the surgical operation, postoperative management, coagulation factor replacement therapy and accompanying therapy, as well as the features of anesthesia, which allowed a surgical intervention without any hemorrhagic and infectious complications.

[Psychopathological features of victimity in hemophiliacs].

Aim: To study psychopathological features of victimity in hemophiliacs.

Material And Methods: Thirty-one men with hemophilia, aged 17-63 years, mean age 33.43±9.

Wound analgesia in a patient with hemophilia in a highly traumatic operation.

Aim: The aim of the study was to describe the use of the wound analgesia method in a patient with hemophilia in the case of a clinical case.

Materials And Methods: A patient with severe hemophilia A underwent postoperative analgesia after total knee replacement (within the first 48 hours) with an extended infusion of local anesthetic (ropivacaine) into the wound.

Results: During the first 8 hours, the patient received 20 mg of morphine (with the aid of a device for patient-controlled analgesia), the pain level ranged from 7 to 4 points.

Effect of Erythrocyte Density on Blood Clot Properties in Healthy Individuals and in Patients with Hemophilia A.

We measured specific volume and hematocrit of blood clots prepared from the whole blood of patients with hemophilia A and healthy male volunteers. It was shown that in the hematocrit range of 43.5-52.

[Thrombotic events in patients with hemophilia].

The paper describes 4 clinical cases of thrombotic events (pulmonary embolism, deep vein thrombophlebitis, acute myocardial infarction, ischemic stroke) that have occurred in patients with hemophilia. It discusses the possible causes of their development and methods for their prevention and treatment. Controlled natural hypocoagulation, in which the dose of an administered deficient factor decreases to such an extent that in order to maintain the safe level of hypocoagulation (plasma factor activity is 15-20%; activated partial thromboplastin time is 1.

Prediction of Intraoperative Blood Loss during Total Knee Arthroplasty in HCV+ and HCV- Patients with Hemophilia A.

We examined HCV+ and HCV- hemophilia A patients with knee arthropathy and hematocrit above 38.5%. The mean density of erythrocytes was studied by the phthalate method, intraoperative blood loss was assessed gravimetrically.

[The specific features of pain syndrome in patients with hemophilia].

Aim: to study the nature of pain in hemophilic arthropathy and its prevention ways used by patients with hemophilia.

Subjects And Methods: A prospective, multicenter, cross-sectional study was conducted to interview 136 patients with hemophilia A or B. The survey included 32 points, including questions about drug and nondrug pain treatment, as well as questionnaires to assess the severity of pain and its impact on daily life (Brief Pain Inventory) and those to identify a neuropathic pain component (PainDetect questionnaire).

Effect of Hematocrit and Erythrocyte Density on Intraoperative Blood Loss in Hemophilia A Patients During Total Knee Arthroplasty.

Intraoperative blood loss during total knee arthroplasty in patients with hemophilia varies over a wide range (from 300 to 3000 ml). The reasons have not been clarified yet. We studied the dependence of intraoperative blood loss during total knee arthroplasty in patients with hemophilia A on hematocrit and mean erythrocyte density.

[THE ROLE OF THE COMBINATION OF INFLAMMATORY PROCESSES IN THE JOINTS AND ALTERED REGIONAL MICROCIRCULATION IN THE DEVELOPMENT OF HEMOPHILIC ARTHROPATHY].

To study the role of the combination of inflammatory processes in the joints and altered regional microcirculation as well as factors influencing them in the development of hemophilic arthropathy in 82 patients with recurrent hemarthrosis of the knee and ankle joints by computed IR thermography, laser Doppler flowmetry, and bioimpedancometry for determining fatty and muscle tissue mass. It was shown that deviation of body mass from the normal value were pathogenetically associated with different variants of hemophilic arthropathy. Its risk factors in the patients with continuously recurrent hemarthrosis include epiarticular perfusion, elevated body temperature, low BMI, and muscle mass deficit in excess of 2 kg.

[The particularities of acute surgical diseases treatment of abdominal cavity organs in patients with haemophilia].

The experience of treatment of 366 patients with haemophilia who were urgently hospitalized in hеmatological Scientific Center over the last 10 years is presented in the article. There were 114 (31.1%) patients with acute diseases of abdominal cavity organs, 150 (41%) patients with bleeding from upper gastrointestinal tract, 102 (27.

[Mechanisms of comorbidity in hemophilia patients].

Aim: To study the somatic status of patients with varying degrees of hemophilia, the mechanisms of comorbidity from the results of studies of systemic microcirculation (MC), body composition, and key metabolic parameters.

Subjects And Methods: One hundred and twenty hemophilia patients were examined. The authors studied their viscera; MC by laser Doppler flowmetry; body composition parameters by bioelectrical impedance; and blood cholesterol, albumin, and iron levels.

Experience of recombinant activated factor VII usage during surgery in patients with haemophilia with inhibitors.

Inhibitor development is one of the most challenging complications of haemophilia management. Haemostatic control in patients with haemophilia with inhibitors can be difficult, and is especially risky in those undergoing surgical interventions. Most haemophilia patients with inhibitors suffer from chronic joint disease requiring surgical correction due to recurrent bleeding episodes.

[Therapy of acute massive blood loss in a hemophilic patient: case report].

A case is reported of management of massive intraoperative blood loss in a male patient with severe hemophilia. Extirpation of hip pseudotumor with one-stage osteosynthesis with an intramedullary joint-pin in a 43 year old male patient was accompanied with 7.5 l blood loss.