Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study.

Background: Peri-implant mucositis (PIM) is a pathological precursor of peri-implantitis, but its pattern of conversion to peri-implantitis is unclear and complicated to diagnose clinically, while none of the available protocols yield complete disease resolution. The aim of this study was the evaluation of PIM responsiveness to standard anti-infective mechanical treatment (AIMT) at clinical and biomarker levels, and estimation of the diagnostic capacity of bone markers as surrogate endpoints and predictors.

Methods: Systemically healthy outpatients presenting one implant exhibiting clinical signs of inflammation confined within the soft tissue (PIM) and one healthy control (HC) implant at a non-adjacent position were included.

Diagnostic value of VEGF in peri-implantitis and its correlation with titanium particles: A controlled clinical study.

Objectives: VEGF is prototypic marker of neovascularization, repeatedly proposed as intrinsic characteristic of peri-implantitis. This study aimed to assess pattern of VEGF in peri-implantitis, its correlation with titanium particles (TPs) and capacity as respective biomarker.

Material And Methods: Pathological specificity of VEGF was assessed in peri-implant granulations using immunohistochemistry, periodontal granulations represented Ti-free positive controls.

Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study.

Peri-implant diseases are an emerging public health problem, and it's considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI.

Study on the immunopathological effect of titanium particles in peri-implantitis granulation tissue: A case-control study.

Objectives: To identify titanium particles (TPs) in biopsy specimens harvested from peri-implantitis lesions and secondarily to study the histopathological characteristics in peri-implantitis compared to periodontitis, in order to evaluate whether the presence of TPs could alter respective inflammatory patterns.

Material And Methods: Biopsies containing granulation tissue were harvested during routine surgical treatment in 39 peri-implantitis cases and 35 periodontitis controls. Serial sections were obtained using titanium-free microtome blades.

Application of Semipermanent Cements and Conventional Cement with Modified Cementing Technique in Dental Implantology.

Objectives: The aim of this study was to evaluate the influence of artificial ageing on the retention force of original semipermanent cements, as well as the possibility of using conventional cements for semipermanent cementation with adequate modification of the cementing protocol.

Materials And Methods: Forty CoCrMo alloy crowns were divided in four groups (each group n=10) and fixed with two semipermanent cements (resin-based and glass ionomer-based cements) and one conventional (zinc phosphate), using conventional and modified cementation techniques on titanium abutments. The samples were stored in humid conditions for 24 hours at 37°C and subjected to thermocycling (500 cycles) and mechanical cyclic loading (7 days, 3, 6, 9 and 12 months function simulation).

Treatment of Early Developed Peri-Implantitis in Fibula Graft Site.

The fibula microvascular free flap technique and placement of dental endosseous implants seem to be viable options for reconstructing the mandible, following a resective jaw surgery. The causes of early failures of implants include bone overheating, latent infection by surgical trauma, the factors related with the implant, and overcompression. This case report reviews the mechanisms of early post-implantation bone loss, and suggests the course of treatment for early peri-implantitis for implants that show no mobility.

Is the personalized approach the key to improve clinical diagnosis of peri-implant conditions? The role of bone markers.

Background: Study objectives were 1) to estimate diagnostic capacity of clinical parameters, receptor activator of nuclear factor kappa-B (RANKL) and osteoprotegerin (OPG) to diagnose healthy peri-implant condition (HI), peri-implant mucositis (PIM) and peri-implantitis (PIMP) by assessing respective diagnostic accuracy, sensitivity, specificity and diagnostic ranges 2) to develop personalized diagnostic model (PDM) for implant monitoring.

Methods: Split-mouth study included 126 patients and 252 implants (HI = 126, PIM = 57, and PIMP = 69). RANKL and OPG concentrations were estimated in peri-implant crevicular fluid using enzyme-linked immunosorbent assay method and assessed with clinical parameters using routine statistics, while the diagnostic capacity of individual parameters and overall clinical diagnosis were estimated using classifying algorithms.

Association of Cytokine Gene Polymorphism with Peri-implantitis Risk.

Purpose: To investigate whether polymorphisms of cluster of differentiation 14 (CD14), tumor necrosis factor alpha (TNFα), interleukin (IL)6, IL10, and IL1ra genes are associated with the risk of peri-implantitis susceptibility in patients with dental implants in the Serbian population.

Materials And Methods: Isolated DNA from the blood was used for IL10-1082, TNFα-308, IL6-174, CD14-159, and interleukin 1 receptor antagonist (IL1ra) genotyping using polymerase chain reaction (PCR)-based methodology. Clinical parameters included: peri-implant pocket depth (PPD), Plaque Index (PI), Gingival Index (GI), bleeding on probing (BOP), and radiologic bone loss.

Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism.

Background/aim: Postoperative condylar position is a substantial concern in surgical correction of mandibular prognathism. Orthognathic surgery may change condylar position and this is considered a contributing factor for early skeletal relapse and the induction of temporomandibular disorders. The purpose of this study was to evaluate changes in condylar position, and to correlate angular skeletal measurements following bimaxillary surgery.

Decompression as an effective primary approach to large radicular cyst in the maxillary sinus--A case report.

Introduction: Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a large maxillary cyst.

Impact of dental implant insertion method on the peri-implant bone tissue--an experimental study.

Background/aim: The function of dental implants depends on their stability in bone tissue over extended period of time, i.e. on osseointegration.

The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: a pathohistologic study.

Background/aim: A wide range of resorbable and non-resorbable membranes have been investigated over the last two decades. The barrier membrane protects the defect from ingrowth of soft tissue cells and allows bone progenitor cells to develop bone within a blood clot that is formed beneath the barrier membrane. The membranes are applied to reconstruct small bony defect prior to implantation, to cover dehiscences and fenestrations around dental implants.

[Histopathological evaluation of bone regeneration using human resorbable demineralized membrane].

Background/aim: Filling a bone defect with bone substitution materials is a therapy of choice, but the infiltration of connective tissue from the mucoperiostal flap may compromise a healing of bone substitutions with bony wall defects. Application of membrane as a barrier is indicated as a solution to this problem. The aim of this study was to show a pathohistological view of bone regeneration and the significance of human resorbable demineralized membrane (HRDM), 200 microns thick in bone regeneration regarding mandibular defects in an experiment on dogs.

Clinical parameters of the local anesthetic effects of bupivacaine applied with and without a vasoconstrictor in oral implantology.

Background/aim: Bupivacaine (Marcaine), homologue of mepivacaine, chemically related to lidocaine, is used as a local anesthetic for local infiltration, peripheral nerve block, retrobulbar block, symphathetic block, and caudal and epidural anesthesia. The aim of this investigation was to determine and to compare clinical parameters of the local anesthetic effects of bupivacaine applied with and without a vasoconstrictor.

Methods: This investigation included a total of 30 randomly selected patients, who ranged in age from 30-60 years, with partial or total anodontia in the molar region of the mandible.

[Mobility of B.C.T. dental implants inserted by one- and two-phase surgical method--an experimental study].

Background/aim: Achievement of the osseointegration of dental implants is of crucial importance for their long-term survival. One of the factors that influence the osseointegration is a surgical method of implantation. The outcome of osseointegration can be evaluated on the basis of implant mobility in bone.

[Possibilty of the lower third molar eruption--radiographic analysis].

Background/aim: To assess the possibility of the eruption of the lower third molar on the basis of the measured parameters: retromolar space, mesiodistal crown width of a molar and the third molar angulation.

Methods: The investigation included 104 patients both sexes (43 boys, and 61 girls), 16 to 25 years old (mean age, 18 years). It was performed using the orthopanthomographic radiographs analysis of those patients.

[Possibility of the use of serological method for the determination of immunoglobuline A antibody against early antigene of Epstein-Barr virus as a marker in the diagnosis of nasopharyngeal tumors].

Background/aim: According to the data from immunological, biological and molecular researches, there is a close association between the undifferentiated carcinoma of nasopharyngeal type (UCNT) and Epstein-Barr virus (EBV). To use IgA EA antibody as a serological marker in our patients with nasopharyngeal carcinoma from a clinical viewpoint.

Methods: 91 patients were followed in the period from 1989-1998.