Publications by authors named "Zoran Milijasevic"
Article Synopsis
- Middle-aged adults with high pulse pressure are at greater risk for dementia, and the Guardian device aims to reduce this risk by modifying blood flow in the carotid artery.
- In a study involving 10 sheep, the Guardian was implanted for 3 to 8 months, and no adverse effects were reported, indicating it is safe for use.
- The device showed promising results with minimal movement and no signs of complications in the carotid artery, but further research is needed to assess its effectiveness for human use.
Background: It has been established that the central elastic arteries of the mammalian circulation dampen the high pulse pressure emanating from the left ventricle, so that the pulsations in distal arterioles, such as in the cerebral circulation, are of lower amplitude than more centrally. However, the contribution of the common carotid artery (CCA) to protection of the cerebral microvasculature from high pulse pressure is not known, specifically to what extent viscoelastic energy dissipation in the arterial wall might contribute to the shock absorbing function of the large conduit arteries.
Methods: Young adult sheep (n = 6) were anaesthetised and their CCAs (n = 7) exposed.