Statin-associated incident diabetes: a literature review.

Objective: To evaluate available evidence for incident diabetes associated with statin use and offer some practical management considerations.

Data Sources: A literature search was performed using MEDLINE from 2000 to October 2013. The following MESH terms and text key words alone or in combination were included: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, HMG-CoA reductase inhibitors, statins, incident diabetes, new-onset diabetes, insulin resistance, impaired insulin secretion, meta-analysis, cohort study, and observational study.

Intravenous N-acetylcysteine in the prevention of contrast media-induced nephropathy.

Objective: To define the clinical role of intravenous N-acetylcysteine for prophylaxis of contrast-induced nephropathy (CIN).

Data Sources: Randomized controlled clinical trials were identified using a search of MEDLINE (1990-September 2010) with the search terms acetylcysteine, N-acetylcysteine, NAC, intravenous, IV, nephropathy, nephrotoxic, radiocontrast, contrast, and media. The search was limited to studies published in English.

Ticagrelor: a novel oral antiplatelet agent.

Objective: To review the pharmacology, clinical efficacy, and tolerability of ticagrelor and to discuss implications for use in the elderly.

Data Source: A literature search was conducted in MEDLINE from 1966 to July 2010 using the MESH terms and key words AZD6140, ticagrelor, P2Y12 receptor antagonist. The search was limited to studies in English language with human subjects.