Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression.

Intravenous anesthetics play a crucial role during surgery. Etomidate, a commonly used intravenous anesthetic agent, is prized for its rapid onset and smooth induction of anesthesia. However, it has a pronounced adverse effect on adrenal function suppression.

Benzylpiperidine derivatives as new dual μ-opioid and σ receptor ligands with potent antinociceptive effects.

Dual-acting μ-opioid receptor (MOR)/sigma-1 receptor (σR) ligands have displayed promise in exerting robust antinociceptive effects while reducing opioid-related side effects. To discover safer and more effective analgesics, we designed, prepared, and evaluated 30 benzylpiperidine derivatives as dual MOR and σR ligands. The obtained benzylpiperidine analogs were tested for MOR and σR binding affinity in vitro.

Machine Learning-Enabled Optical Architecture Design of Perovskite Solar Cells.

Perovskite solar cells, emerging as a cutting-edge solar energy technology, have demonstrated a power conversion efficiency (PCE) of >26%, which is below the theoretical limit of 33%. This study, employing a combination of neural network models and high-throughput simulation calculations, taking the single-junction FAPbI cell as an illustrative example, indicates that a pyramid structure, in comparison of a planar one, can increase the highest to 27.4 mA/cm and the PCE to 28.

Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice.

Chronic pain is a common public health problem and remains an unmet medical need. Currently available analgesics usually have limited efficacy for the treatment of chronic pain, including neuropathic pain and persistent inflammatory pain, or they are accompanied by many adverse side effects. The voltage-gated calcium channel blocker (pregabalin) and potassium channel openers (flupirtine and retigabine) have been widely used for the management of chronic pain, but their effectiveness in combination is unclear.

[Multiplicity and prevention for patients with hydrocephalus secondary to severe traumatic brain injury after surgery].

Objective: To investigate the factors for hydrocephalus secondary to severe traumatic brain injury after surgery, and to explore a new theory and guideline for clinical early prevention and treatment for hydrocephalus.


Methods: The clinical data regarding 107 patients with severe traumatic brain injury, who were admitted to our hospital from June 2010 to June 2013, were analyzed. Logistic multi-factor regression was used to analyze the different factors including ages, gender, the Glasgow coma scale (GCS) score before or after surgery, the situation of ventricular system bleeding secondary to surgery, the situation of midbrain aqueduct and ambient cistern before or after surgery, the relationship between early lumbar puncture and the hydrocephalus.

Microsurgical and tractographic anatomical study of insular and transsylvian transinsular approach.

This study is to define the operative anatomy of the insula with emphasis on the transsylvian transinsular approach. The anatomy was studied in 15 brain specimens, among five were dissected by use of fiber dissection technique; diffusion tensor imaging of 10 healthy volunteers was obtained with a 1.5-T MR system.

[Expression of neuropeptides ghrelin and Nesfatin-1 in kainic acid kindling rats].

Objective: To observed the post-seizure expression level of neuropeptides ghrelin and Nesfatin-1 between the untreated and treated groups in kainic acid-kindling rats and understand the significance of their basic expressions.

Methods: The male S-D rats were divided randomly into NS and VPA groups after seizure. Each group was divided into 7 subgroups of 3 h, 6 h, 12 h, 24 h, 3 d, 7 d and 14 d.

[Microsurgical anatomy and surgical approach of the ambient cistern].

Objective: to describe detailed anatomy and compare four surgical approach of the ambient cistern, to assist in the process of conceptualizing a reliable surgical approach to allow for a successful course of surgery.

Methods: The microsurgical anatomy of the ambient cistern and four surgical approach was studied in 12 formalin-fixed brain specimens (24 hemispheres). Four simply formalin-fixed, the cerebral arteries of eight brain specimens were perfused with colored silicone, and they were dissected with the aid of an operating microscope.