Sensors (Basel)
January 2025
To enable person detection tasks in surveillance footage to be deployed on edge devices and their efficient performance in resource-constrained environments in real-time, a lightweight person detection model based on YOLOv8n was proposed. This model balances high accuracy with low computational cost and parameter size. First, the MSBlock module was introduced into YOLOv8n.
View Article and Find Full Text PDFCellulose nanocrystals (CNCs) are known to self-assemble into a left-handed chiral nematic lyotropic liquid crystalline phase in water. When captured in the solid state, this structure can impart films with photonic properties that make them promising candidates in photonics, sensing, security, and other areas. Unfortunately, the intrinsic hydrophilicity of CNCs renders these iridescent films susceptible to moisture, thereby limiting their practicality.
View Article and Find Full Text PDFThe oocyte maturation defect 6 is an autosomal recessive hereditary disease caused by a homozygous variant in ZP2 gene. It is characterized by female primary infertility due to an abnormally thin zona pellucida (ZP) and defective sperm binding. Here we identified a compound heterozygous variant (c.
View Article and Find Full Text PDFPopulation aging and carbon emissions are critical issues for China's development. As an enormous complex system, the population and the carbon emission development process have non-negligible differences in time, space, and speed. Therefore, this paper first demonstrates the spatial and temporal correlation between population aging and carbon emissions from 1995 to 2020, then uses the allometric growth analysis model to make a cross-sectional temporal comparison and a vertical spatial comparison of the relationship and development rate of the two, and finally uses the ridge regression model to determine the forces and interaction mechanisms of the factors influencing the relationship between population aging and carbon emissions at allometric rates.
View Article and Find Full Text PDFThe quest for advanced water purification technologies has been vigorous over recent decades, motivated by the promise of ever more efficient, greener, and affordable tools. Halloysite nanotubes (HNTs) are naturally-occurring materials that have shown potential as dye sorbents. Unfortunately, these nanoclays suffer from low permeation during water treatment, which limits their widespread application.
View Article and Find Full Text PDFPrevious studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypes among these patients. Here, 793 patients with HCM were recruited at an average follow-up of 32.78 ± 27.
View Article and Find Full Text PDFACS Appl Mater Interfaces
February 2023
Gels are useful materials for drug delivery, wound dressings, tissue engineering, and 3D printing. These various applications require gels with different mechanical properties that can be easily tuned, also preferably excluding the use of chemical additives, which can be toxic or harmful to the body or environment. Here, we report a novel strategy to synthesize cellulose nanocrystal (CNC) gels with tunable mechanical properties.
View Article and Find Full Text PDFBackground: Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear.
Objectives: The purpose of this study is to report the variant spectrum in a Chinese cohort with suspected BrS and to analyze their distinct clinical and electrocardiographic features.
Marfan syndrome (MFS) is a life-threatening autosomal dominant genetic disorder of connective tissue caused by the pathogenic mutation of FBN1. Whole exome sequencing and Sanger sequencing were performed to identify the pathogenic mutation. The transcriptional consequence of the splice-altering mutation was analyzed via minigene assays and reverse-transcription PCR.
View Article and Find Full Text PDFObjective: is associated with a recessive form of pediatric cardiomyopathy accompanied by musculoskeletal and craniofacial abnormalities. Heterozygous truncating variants in this gene (tv) have recently been confirmed as a cause of autosomal dominant hypertrophic cardiomyopathy (HCM). Whether is also implicated in HCM in East Asia and the effect of missense variants in on HCM remains unresolved.
View Article and Find Full Text PDFBackground: Coarctation of the aorta (CoA) is a common congenital cardiovascular malformation with aortic narrowing in the region of the ligamentum arteriosum. Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy that is characterized by left ventricular wall thickening and likely left ventricular outflow tract (LVOT) obstruction. They are two irrelevant diseases, and their coexistence has not been reported before.
View Article and Find Full Text PDFFront Cardiovasc Med
November 2021
Danon disease (DD) is a rare glycogen storage lysosomal disorder caused by mutations in the gene. Patients with DD are usually characterized clinically by severe multisystem syndromes. We describe a specific family with a novel pathogenic splice-altering mutation in the gene (c.
View Article and Find Full Text PDFMutations in genes encoding sarcomere and cytoskeletal proteins are major causes of primary dilated cardiomyopathy (DCM). Likewise, ischemic myocardial injury is a major cause of secondary cardiac remodeling, which, in a subset, is severe and resembles DCM. The latter is referred to as ischemic dilated cardiomyopathy (IDCM).
View Article and Find Full Text PDFBMC Cardiovasc Disord
August 2021
Background: The bicuspid aortic valve (BAV) is prone to ascending aortic dilatation (AAD) involving both the tubular segment and the aortic root. The genetic factor was proposed as one of the most important mechanisms for AAD. We hypothesized that the rare genetic variants mainly contribute to the pathogenesis of aortic roots in affected individuals.
View Article and Find Full Text PDFBackground: The genetic basis of a considerable fraction of hypertrophic cardiomyopathy (HCM) cases remains unknown. Whether the gene encoding RNA binding motif protein 20 (RBM20) is implicated in HCM and the correlation of clinical characteristics of RBM20 heterozygotes with HCM remain unresolved. We aimed to investigate the association between RBM20 variants and HCM.
View Article and Find Full Text PDFThoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637).
View Article and Find Full Text PDFBackground Aortic dissection (AD) is one of the most life-threatening cardiovascular diseases that exhibit high genetic heterogeneity. However, it is unclear whether variants within the gene can cause AD. Therefore, we intend to determine whether is a causative gene of AD.
View Article and Find Full Text PDFBackground: Although studies have identified hundreds of genetic variants associated with asthma risk, a large fraction of heritability remains unexplained, especially in Chinese individuals.
Methods: To identify genetic risk factors for asthma in a Han Chinese population, 211 asthma-related genes were first selected based on database searches. The genes were then sequenced for subjects in a Discovery Cohort (284 asthma patients and 205 older healthy controls) using targeted next-generation sequencing.
Background: Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. Hyaluronidase 1 (HYAL1) was found to be upregulated in fibroblasts from IPF patients, and overexpression of HYAL1 could prevent human fetal lung fibroblast proliferation. However, the genetic correlation between the HYAL1 and IPF or connective tissue diseases related interstitial lung disease (CTD-ILD) has not been determined.
View Article and Find Full Text PDFFront Med
October 2021
We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian (SHL), a traditional Chinese patent medicine, in treating cases of COVID-19. A total of 176 patients received SHL by three doses (56 in low dose, 61 in middle dose, and 59 in high dose) in addition to standard care. The control group was composed of 59 patients who received standard therapy alone.
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