A Lightweight Person Detector for Surveillance Footage Based on YOLOv8n.

To enable person detection tasks in surveillance footage to be deployed on edge devices and their efficient performance in resource-constrained environments in real-time, a lightweight person detection model based on YOLOv8n was proposed. This model balances high accuracy with low computational cost and parameter size. First, the MSBlock module was introduced into YOLOv8n.

Durable Hydrophobic Iridescent Films with Tunable Colors from Self-Assembled Cellulose Nanocrystals.

Cellulose nanocrystals (CNCs) are known to self-assemble into a left-handed chiral nematic lyotropic liquid crystalline phase in water. When captured in the solid state, this structure can impart films with photonic properties that make them promising candidates in photonics, sensing, security, and other areas. Unfortunately, the intrinsic hydrophilicity of CNCs renders these iridescent films susceptible to moisture, thereby limiting their practicality.

A Compound Heterozygous Pathogenic Variant in ZP2 Gene Causes Female Infertility.

The oocyte maturation defect 6 is an autosomal recessive hereditary disease caused by a homozygous variant in ZP2 gene. It is characterized by female primary infertility due to an abnormally thin zona pellucida (ZP) and defective sperm binding. Here we identified a compound heterozygous variant (c.

Study on the spatial and temporal correlation and allometric growth mechanism between population aging and carbon emissions in China.

Population aging and carbon emissions are critical issues for China's development. As an enormous complex system, the population and the carbon emission development process have non-negligible differences in time, space, and speed. Therefore, this paper first demonstrates the spatial and temporal correlation between population aging and carbon emissions from 1995 to 2020, then uses the allometric growth analysis model to make a cross-sectional temporal comparison and a vertical spatial comparison of the relationship and development rate of the two, and finally uses the ridge regression model to determine the forces and interaction mechanisms of the factors influencing the relationship between population aging and carbon emissions at allometric rates.

Cellulose nanocrystal/halloysite nanotube composite aerogels for water purification.

The quest for advanced water purification technologies has been vigorous over recent decades, motivated by the promise of ever more efficient, greener, and affordable tools. Halloysite nanotubes (HNTs) are naturally-occurring materials that have shown potential as dye sorbents. Unfortunately, these nanoclays suffer from low permeation during water treatment, which limits their widespread application.

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature.

Previous studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypes among these patients. Here, 793 patients with HCM were recruited at an average follow-up of 32.78 ± 27.

Cellulose Nanocrystal Gels with Tunable Mechanical Properties from Hybrid Thermal Strategies.

Gels are useful materials for drug delivery, wound dressings, tissue engineering, and 3D printing. These various applications require gels with different mechanical properties that can be easily tuned, also preferably excluding the use of chemical additives, which can be toxic or harmful to the body or environment. Here, we report a novel strategy to synthesize cellulose nanocrystal (CNC) gels with tunable mechanical properties.

Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population.

Background: Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear.

Objectives: The purpose of this study is to report the variant spectrum in a Chinese cohort with suspected BrS and to analyze their distinct clinical and electrocardiographic features.

Splice-Altering Mutations in Marfan Syndrome: A Case Report and Literature Review.

Marfan syndrome (MFS) is a life-threatening autosomal dominant genetic disorder of connective tissue caused by the pathogenic mutation of FBN1. Whole exome sequencing and Sanger sequencing were performed to identify the pathogenic mutation. The transcriptional consequence of the splice-altering mutation was analyzed via minigene assays and reverse-transcription PCR.

The Involvement of in Hypertrophic Cardiomyopathy in East Asia.

Objective: is associated with a recessive form of pediatric cardiomyopathy accompanied by musculoskeletal and craniofacial abnormalities. Heterozygous truncating variants in this gene (tv) have recently been confirmed as a cause of autosomal dominant hypertrophic cardiomyopathy (HCM). Whether is also implicated in HCM in East Asia and the effect of missense variants in on HCM remains unresolved.

Aortic Coarctation Associated With Hypertrophic Cardiomyopathy in a Woman With Hypertension and Syncope: A Case Report With 8-Year Follow-Up.

Background: Coarctation of the aorta (CoA) is a common congenital cardiovascular malformation with aortic narrowing in the region of the ligamentum arteriosum. Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy that is characterized by left ventricular wall thickening and likely left ventricular outflow tract (LVOT) obstruction. They are two irrelevant diseases, and their coexistence has not been reported before.

Case Report: A Novel Splice-Altering Mutation Causes Cardiac-Only Danon Disease.

Danon disease (DD) is a rare glycogen storage lysosomal disorder caused by mutations in the gene. Patients with DD are usually characterized clinically by severe multisystem syndromes. We describe a specific family with a novel pathogenic splice-altering mutation in the gene (c.

Shared Genetic Etiology of Primary Dilated Cardiomyopathy and Ischemic Dilated Cardiomyopathy.

Mutations in genes encoding sarcomere and cytoskeletal proteins are major causes of primary dilated cardiomyopathy (DCM). Likewise, ischemic myocardial injury is a major cause of secondary cardiac remodeling, which, in a subset, is severe and resembles DCM. The latter is referred to as ischemic dilated cardiomyopathy (IDCM).

Aortic root aortopathy in bicuspid aortic valve associated with high genetic risk.

Background: The bicuspid aortic valve (BAV) is prone to ascending aortic dilatation (AAD) involving both the tubular segment and the aortic root. The genetic factor was proposed as one of the most important mechanisms for AAD. We hypothesized that the rare genetic variants mainly contribute to the pathogenesis of aortic roots in affected individuals.

RBM20 Is a Candidate Gene for Hypertrophic Cardiomyopathy.

Background: The genetic basis of a considerable fraction of hypertrophic cardiomyopathy (HCM) cases remains unknown. Whether the gene encoding RNA binding motif protein 20 (RBM20) is implicated in HCM and the correlation of clinical characteristics of RBM20 heterozygotes with HCM remain unresolved. We aimed to investigate the association between RBM20 variants and HCM.

Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study.

Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637).

Variants Cause Aortic Dissection by Activating TGF-β-Signaling Pathway.

Background Aortic dissection (AD) is one of the most life-threatening cardiovascular diseases that exhibit high genetic heterogeneity. However, it is unclear whether variants within the gene can cause AD. Therefore, we intend to determine whether is a causative gene of AD.

Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population.

Background: Although studies have identified hundreds of genetic variants associated with asthma risk, a large fraction of heritability remains unexplained, especially in Chinese individuals.

Methods: To identify genetic risk factors for asthma in a Han Chinese population, 211 asthma-related genes were first selected based on database searches. The genes were then sequenced for subjects in a Discovery Cohort (284 asthma patients and 205 older healthy controls) using targeted next-generation sequencing.

A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese.

Background: Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. Hyaluronidase 1 (HYAL1) was found to be upregulated in fibroblasts from IPF patients, and overexpression of HYAL1 could prevent human fetal lung fibroblast proliferation. However, the genetic correlation between the HYAL1 and IPF or connective tissue diseases related interstitial lung disease (CTD-ILD) has not been determined.

Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial.

We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian (SHL), a traditional Chinese patent medicine, in treating cases of COVID-19. A total of 176 patients received SHL by three doses (56 in low dose, 61 in middle dose, and 59 in high dose) in addition to standard care. The control group was composed of 59 patients who received standard therapy alone.