Prodigiosin hydrogel to promote healing of trauma-infected multidrug-resistant mice wounds.

Wound infections caused by Multidrug-resistant (MRSA) have been regarded as a challenging problem in clinic for the long time. In this study, based on the excellent antimicrobial effect of prodigiosin(PG) and the ability of hydrogel dressing in terms of tissue repair and regeneration, we prepared the PG hydrogel as a treatment for the wound infection induced by MRSA. Rheological tests indicated that PG hydrogel as a semi-solid gel had good mechanical properties.

An activatable azophenyl fluorescent probe for hypoxic fluorescence imaging in living cells.

Cellular hypoxia is a common pathological process in various diseases. Detecting cellular hypoxia is of great scientific significance for early diagnosis of tumors. The hypoxia fluorescence probe analysis method can efficiently and conveniently evaluate the hypoxia status in tumor cells.

ALKBH5-mediated mA demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.

HS3ST3B1-IT1 was identified as a downregulated long noncoding RNA in osteoarthritic cartilage. However, its roles and mechanisms in the pathogenesis of osteoarthritis (OA) are unclear. In this study, we demonstrated that the expressions of HS3ST3B1-IT1 and its maternal gene HS3ST3B1 were downregulated and positively correlated in osteoarthritic cartilage.

Experimental Investigation on a Novel Temperature-Controlled Phase Change Aggregate Concrete: Thermo-Mechanical Properties and Hydration Heat Control.

To reduce the structural deterioration of mass concrete structures from temperature cracks, and lower energy consumption caused by the traditional mass concrete hydration heat cooling process, this paper reports the preparation of concrete temperature-controlled phase change aggregate (PCA) by a vacuum compaction method using light and high-strength black ceramite and No. 58 fully refined paraffin wax as phase change material (PCM), and the encapsulation technology of the aggregate by using superfine cement and epoxy resin. Further, through laboratory tests, the cylinder compressive strength, thermal stability and mixing breakage rate of the encapsulated PCA were tested, and the differences in mechanical properties such as compressive strength, flexural strength and splitting tensile strength between phase change aggregate concrete (PCAC) and ordinary concrete were studied.

Research on aeromagnetic data error analysis and processing of multi-rotor UAV based on variational mode decomposition algorithm.

Aeromagnetic survey of multi-rotor UAV is widely used in small and medium-sized mineral resources survey, engineering investigation, non-explosive detection and other fields due to its advantages of high safety, low cost and convenient operation. The original data of UAV aeromagnetic survey includes interference from external environment, interference from UAV platform and interference from airborne electromagnetic equipment. The interference is mainly shown as striping anomaly along the direction of the survey line in the aeromagnetic anomaly map, which affects the accuracy of aeromagnetic compensation and information detection of geological anomaly body, thus affecting the accuracy of interpretation of geological anomaly body.

The Efficacy and Safety of Dingkun Pill in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: Dingkun Pill (DKP) is a proprietary Chinese medicine that has been utilized for patients with gynecological diseases, and its clinical application has been widely accepted in China. However, the effects of DKP on reproduction and metabolism in women with polycystic ovary syndrome (PCOS) have never been systematically evaluated. Our objective was to evaluate the efficacy and safety of DKP in treating reproductive and metabolic abnormalities with PCOS.

Research on Temperature Compensation of Multi-Channel Pressure Scanner Based on an Improved Cuckoo Search Optimizing a BP Neural Network.

A multi-channel pressure scanner is an essential tool for measuring and acquiring various pressure parameters in aerospace applications. It is important to note, however, that the pressure sensor of each of these channels will drift significantly with the increase in the temperature range of the pressure measurement, and the output voltage of each of these channels will show nonlinear characteristics, which will constrain the improvements in the accuracy of the measurement. In the regression fitting process, it is difficult to fit nonlinear data with the traditional least-squares method, which leaves pressure measurement accuracy unsatisfactory.

Hydroxysafflor Yellow A (HSYA) Protects Endplate Chondrocytes Against IL-1-Induced Injury Through Promoting Autophagy.

Background: Intervertebral disc degeneration (IDD) refers to intractable pain in patients' waist and legs, which is caused by internal structural disorder and degeneration of intervertebral. This disease severely affects the quality-of-life of people. It has been reported that hydroxysafflor yellow (HSYA), the active ingredient in safflower extract, could inhibit IL-1-induced apoptosis of endplate chondrocytes.

High-Altitude Genetic Selection and Genome-Wide Association Analysis of Yield-Related Traits in L. Using SLAF Sequencing.

The genetic adaptations to harsh climatic conditions in high altitudes and genetic basis of important agronomic traits are poorly understood in L. In this study, an association population of 210 genotypes was used for population structure, selective sweep analysis, and genome-wide association study (GWAS) based on 88,506 single nucleotide polymorphisms (SNPs). We found 965 alleles under the natural selection of high altitude, which included 7 hub genes involved in the response to UV, and flavonoid and anthocyanin biosynthetic process based on the protein-protein interaction (PPI) analysis.

The birth weight of macrosomia influence the accuracy of ultrasound estimation of fetal weight at term.

Objective: To evaluate and analyze the accuracy of ultrasound estimation of the fetal weight of Macrosomia at term.

Method: The instruments used were α6(Aloka; Japan) color Doppler ultrasound imagers, and vinno 80 (feieno; China) with a frequency of 3.5 MHz.

Identification of Flowering Regulatory Networks and Hub Genes Expressed in the Leaves of L. Using Comparative Transcriptome Analysis.

Flowering is a significant stage from vegetative growth to reproductive growth in higher plants, which impacts the biomass and seed yield. To reveal the flowering time variations and identify the flowering regulatory networks and hub genes in , we measured the booting, heading, and flowering times of 66 accessions. The booting, heading, and flowering times varied from 136 to 188, 142 to 194, and 148 to 201 days, respectively.

A novel g-CN nanosheet/AgPO/α-BiO ternary dual Z-scheme heterojunction with increased light absorption and expanded specific surface area for efficient photocatalytic removal of TC.

A novel ternary dual Z-scheme 2D g-CN nanosheet/AgPO/α-BiO (CNN/AP/BO) photocatalyst was successfully synthesized by an deposition and hydrothermal-calcination method. The coupling of AP and BO remarkably enhanced the photocatalytic tetracycline (TC) degradation under visible light illumination, with an optimal removal efficiency of 91.6% (60 min), which can be attributed to the extended visible-light absorption and increased specific surface area owing to the interfacial intimate coupling with well-matched energy band positions between semiconductors.

Effects of Tea Consumption on Anthropometric Parameters, Metabolic Indexes and Hormone Levels of Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: Our aim was to conduct a systematic review and meta-analysis to assess the effectiveness and safety of tea supplements for patients with polycystic ovary syndrome (PCOS).

Methods: We conducted searches of the published literature in PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure (CNKI), VIP database, and Wanfang Database in 1985 to September 2021. Data from randomized controlled trials (RCTs) were obtained to assess the effects of tea versus placebo in women with PCOS.

Enhancement of redox capacity derived from O-doping of g-CN/WO nanosheets for the photocatalytic degradation of tetracycline under different dissolved oxygen concentration.

Element doping is an essential method for adjusting band structure, light absorbance and charge transfer, and separation of semiconductors. Besides this, whether the photocatalyst can function in an oxygen-deficient environment is also important. Herein, a novel Z-scheme heterojunction photocatalyst O-doped g-CN/WO (OCN/W) was fabricated and used for the photocatalytic degradation of tetracycline (TC) at different dissolved oxygen concentrations.

LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p.

It is obvious that epigenetic processes influence the evolution of intervertebral disc degeneration (IDD). However, its molecular mechanisms are poorly understood. Long noncoding RNAs (lncRNAs) have been validated to exert vital roles in IDD.

The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a touchy clinical and public health problem worldwide, which adversely affects women's health and health-related comorbidities for lifetime, and represents a tremendous burden for both the family of the patient and for society. According to the diagnostic criteria used and the population studied, the prevalence rate of PCOS is between 6% and 21%. However, current conventional modern medicines for PCOS are only moderately effective at controlling the signs and symptoms, while they are not thoroughly able to prevent complications.

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB.

Background: Mastitis is a common disease occurs in breast-feeding mothers, but published data are poor. This study aimed to study the effects of Tanshinones on treating mastitis.

Methods: Clinical trials performed in 58 breast-feeding mothers were carried out.

Role of lncRNA PART1 in intervertebral disc degeneration and associated underlying mechanism.

Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degeneration disease. Previous studies have demonstrated that long non-coding RNAs (lncRNAs) exert significant roles in serious illnesses. Prostate androgen-regulated transcript 1 (PART1) is an identified lncRNA that has been reported to be a regulator in a number of diseases.

Development of EST-SSR Markers Linked to Flowering Candidate Genes in L. Based on RNA Sequencing.

L. is an important cold-season grass with excellent cold and drought tolerance, good palatability, and nutrition. Flowering time is a key trait that affects forage and seed yield.

Potential Effects of Awn Length Variation on Seed Yield and Components, Seed Dispersal and Germination Performance in Siberian Wildrye ( L.).

Awns, needle-like structures formed on the distal of the lemmas in the florets, are of interest because of their essential roles in seed dispersal, germination and photosynthesis. Previous research has reported the potential benefits of awns in major cereal grasses, yet reports on the agronomic and economic implications of awn length variation in forage grasses remain scarce. This study investigated the variation of awn length among 20 Siberian wildrye populations and the effect of awn length on seed yield and yield components.

Construction of the first high-density genetic linkage map and identification of seed yield-related QTLs and candidate genes in Elymus sibiricus, an important forage grass in Qinghai-Tibet Plateau.

Background: Elymus sibiricus is an ecologically and economically important perennial, self-pollinated, and allotetraploid (StStHH) grass, widely used for forage production and animal husbandry in Western and Northern China. However, it has low seed yield mainly caused by seed shattering, which makes seed production difficult for this species. The goals of this study were to construct the high-density genetic linkage map, and to identify QTLs and candidate genes for seed-yield related traits.

Selection of Suitable Reference Genes for RT-qPCR Gene Expression Analysis in Siberian Wild Rye () under Different Experimental Conditions.

, which is a perennial and self-pollinated grass, is the typical species of the genus , which plays an important role in forage production and ecological restoration. No reports have, so far, systematically described the selection of optimal reference genes for reverse transcriptase quantitative real-time polymerase chain reaction (RT-qPCR) analysis in . The goals of this study were to evaluate the expression stability of 13 candidate reference genes in different experimental conditions, and to determine the appropriate reference genes for gene expression analysis in .

EST-SSR marker development based on RNA-sequencing of E. sibiricus and its application for phylogenetic relationships analysis of seventeen Elymus species.

Background: Elymus L. is the largest genus in the tribe Triticeae Dumort., encompassing approximately 150 polyploid perennial species widely distributed in the temperate regions of the world.

Elymus nutans genes for seed shattering and candidate gene-derived EST-SSR markers for germplasm evaluation.

Background: Elymus nutans and E. sibiricus are two important forage grasses of the genus Elymus. But they are difficult to grow for commercial seed production due to serious seed shattering.