The anti-cholestatic effects of Franch. alone and combined with (A. Jussieu) T. G. Hartley: dual effects on fecal metabolism and microbial diversity.

Drug dosages and combinations are the main factors that affect the efficacy of pleiotropic traditional Chinese medicine (TCM). Franch. (CF) is a representative TCM with multiple effects and is often combined with (A.

Mechanism of Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway.

Background: Fructus mume pills (FMPs) have been clinically proven to be effective for treating ulcerative colitis (UC). However, the therapeutic and protective mechanisms have not been fully studied.

Aim: We aimed to explore the mechanism of FMPs in an acetic acid (AA)-induced ulcerative colitis rat model.

(Wu Mei) Attenuates Acetic Acid-Induced Ulcerative Colitis by Regulating Inflammatory Cytokine, Reactive Oxygen Species, and Neuropeptide Levels in Model Rats.

Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of the large intestine. (FM), a natural food with nutritive and pharmaceutical value, has demonstrated therapeutic efficacy against UC. In this study, we investigated the protective effects and mechanisms of FM against UC.

Nitrogen self-doped porous carbon with layered structure derived from porcine bladders for high-performance supercapacitors.

Nitrogen-doped layered porous carbon has been successfully fabricated from the biomass of porcine bladders via carbonization and KOH activation. The effects of KOH dosage on the structure, composition and capacitive property of carbon were investigated by a variety of means (SEM, HRTEM, XRD, Raman, XPS, BET and electrochemical test). Owing to the unique layered structure and rich heteroatom content of porcine bladders, the sample obtained at a KOH/carbon mass ratio of 2 were endowed with appropriate pore structure, large specific surface area (1881.

Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats.

Cholestasis is a devastating liver condition which is increasing in prevalence worldwide; however, its underlying pathogenic mechanisms remain to be fully elucidated. It was hypothesised that melatonin may alleviate the hepatic injury associated with cholestasis due to its established antioxidant effects. Therefore, the effect and potential anticholestatic properties of melatonin were investigated in rats with α‑naphthylisothiocyanate (ANIT)‑induced liver injury, a common animal model that mimics the cholestasis‑associated liver injury in humans.

Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses.

The present study investigated the anti‑cholestatic effect of melatonin (MT) against α‑naphthyl isothiocyanate (ANIT)‑induced liver injury in rats and screened for potential biomarkers of cholestasis. Rats were administered ANIT by intraperitoneal injection and then sacrificed 36 h later. Serum biochemical parameters were measured and liver tissue samples were subjected to histological analysis.