Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish.

Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that regulates cardiomyocyte proliferation during zebrafish development. Knocking out entire coding sequences leads to impaired cardiomyocyte proliferation, while cardiomyocyte-specific overexpression of promotes cardiomyocyte proliferation.