Publications by authors named "Zongxuan Yang"
Sheep are an important livestock species whose gastrointestinal tract is essential for overall health. Feed contaminants such as bacterial toxins and mycotoxins severely damage the sheep intestine, yet the mechanisms remain mostly elusive partially due to the lack of physiologically relevant in vitro models. Here, we investigated molecular mechanisms underlying deoxynivalenol (DON)-induced toxicity by developing intestinal organoids from isolated intestinal crypts of Hu sheep.
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- Phenanthrene (Phe) is a harmful polycyclic aromatic hydrocarbon commonly found in food, particularly affecting pregnant women and infants.
- A study on pregnant mice revealed that exposure to Phe resulted in significant reproductive issues in male offspring, including reduced testicular weight and altered hormone levels.
- The research highlighted how Phe exposure during pregnancy impairs testicular antioxidant capacity, disrupting the hormonal balance and negatively impacting sperm production in male mice.