Preparation, physicochemical and pharmacological study of 10-hydroxycamptothecin solid dispersion with complexation agent - xylan-nonanoic acid amphiphilic conjugates.

An amphiphilic conjugate of carboxymethyl xylan-nonanoic acid (CX-NA) was synthesized with molecular weight of 38.35 kDa, HLB value of 13.59, and critical micelle concentration of 23.

Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity.

Natural compounds as carriers for hydrophobic drugs have been increasingly used in drug delivery systems. In this study, disodium glycyrrhizin (NaGA), tannic acid (TA) and camptothecin (CPT) were firstly used to prepare the camptothecin solid dispersion (CPT SD). When dissolved in a solution medium, NaGA self-assembled to form micelles and CPT was encapsulated in micelles, meanwhile, TA connected with NaGA through hydrogen bonds to form a contract shell.

Preparation of olmesartan medoxomil solid dispersion with sustained release performance by mechanochemical technology.

Hypertension is a common disease for human with high morbidity and mortality, and olmesartan medoxomil (OM) is widely used in the therapy of hypertension. However, poor water solubility and low bioavailability limit its widespread use. To improve the effect of OM, a ternary OM solid dispersion consisting of hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl methylcellulose (HPMC) was prepared by mechanochemical method.

High yielding, one-step mechano-enzymatic hydrolysis of cellulose to cellulose nanocrystals without bulk solvent.

Traditional methods of enzymatic hydrolysis of cellulose to cellulose nanocrystals (CNCs) are limited due to the low enzymatic efficiency and large amount of waste liquid. The purpose of this study is to improve the yield and production efficiency of CNCs by enzymatic hydrolysis. A one-step mechano-enzymatic hydrolysis method was developed by utilizing the synergy of wet grinding and enzymatic hydrolysis reaction to efficiently prepare CNCs.