Efficacy and prognosis of fertility-preserved hysteroscopic surgery combined with progesterone in the treatment of complex endometrial hyperplasia and early endometrial carcinoma.

Purpose: To evaluate the complete response (CR) rate, recurrence rate and pregnancy outcome of complex endometrial hyperplasia (CEH) and early endometrial carcinoma (EC) patients treated with hysteroscopic surgery combined with progesterone, and to analyze the related influencing factors for prognosis.

Methods: The clinical data of 96 patients histopathologically diagnosed with CEH or early EC and treated with hysteroscopic surgery combined with levonorgestrel-releasing intrauterine system (LNG-IUS) and/or high-efficient megestrole acetale (MA) in our hospital from January 2014 to January 2016 were retrospectively analyzed. The hysteroscopic examination was performed for patients, and the improvement of endometrium was evaluated via curettage every 3 months after treatment.

CircularRNA-9119 promotes the proliferation of cervical cancer cells by sponging miR-126/MDM4.

The aim of this study was to investigate the role of circular RNA-9119 (circ9119) in cervical cancer (CC) and the microRNA-126-3p (miR-126)-based molecular mechanism underlying CC. circ9119 and MDM4 were initially overexpressed, and miR-126 expression was found to be reduced in CC cells and tissues. A series of mimics, inhibitors, overexpressing plasmids or siRNAs were introduced into CC cells to alter the circ9119, miR-126, and MDM4 expressions.

ZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN.

Background: ZNF277 is a transcription factor that is overexpressed in several cancers. However, its clinical role in ovarian cancer (OC) has not been reported yet. The present study aims to investigate the expression of ZNF277 in patients with OC, and to reveal the effects of ZNF277 on the proliferation, migration, and invasion of OC cells.

Up-regulation of miRNA-148a inhibits proliferation, invasion, and migration while promoting apoptosis of cervical cancer cells by down-regulating RRS1.

The purpose of the present study is to figure out the role of miRNA-148a (miR-148a) in growth, apoptosis, invasion, and migration of cervical cancer cells by binding to regulator of ribosome synthesis 1 (RRS1). Cervical cancer and adjacent normal tissues, as well as cervical cancer cell line Caski, HeLa, C-33A, and normal cervical epithelial cell line H8 were obtained to detect the expression of miR-148a and RRS1. Relationship between miR-148a and RRS1 expression with clinicopathological characteristics was assessed.