Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway.

Background: Obesity is an important risk factor for prostate damage. The importance of zinc in male reproductive spermatogenesis and the anti-inflammatory properties of zinc have been studied. However, the role of zinc in obesity-induced prostate proliferation and inflammatory injury and changes in zinc transporters are unknown and require extensive research and validation.

Plasma proteins and coronary atherosclerosis: A Mendelian randomization study.

Coronary atherosclerosis (AS) is a complicated and severe chronic pathological process that contributes to the basis of various cardiovascular diseases, which causes a serious challenge to the global healthcare system. AS is the underlying physiopathological mechanism. Despite recent advances in the research of biomarkers and therapeutic targets for AS, there remain significant limitations in the current targeted therapies for AS.

Deciphering Necroptosis-Associated Molecular Subtypes in Acute Ischemic Stroke Through Bioinformatics and Machine Learning Analysis.

Acute ischemic stroke (AIS) is a severe disorder characterized by complex pathophysiological processes, which can lead to disability and death. This study aimed to determine necroptosis-associated genes in acute ischemic stroke (AIS) and to investigate their potential as diagnostic and therapeutic targets for AIS. Expression profiling data were acquired from the Gene Expression Omnibus database, and necroptosis-associated genes were retrieved from GeneCards.

β-hydroxybutyrate and ischemic stroke: roles and mechanisms.

Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is limited, ketone bodies, predominantly β-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB have been found in the ischemic hemispheres of animal models of stroke, supporting its role in the pathophysiology of cerebral ischemia.

Effects of Silicon Dioxide/Graphene Oxide Hybrid Modification on Curing Kinetics of Epoxy Resin.

In this study, SiO-grafted graphene oxide (GO-SiO) was prepared using the oxygen-containing group on the GO surface as the active site of the reaction. The chemical structure, morphology, and particle size of GO and GO-SiO were carefully investigated by Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, thermogravimetry, transmission electron microscopy, scanning electron microscopy, and atomic force microscopy, and the results proved that the grafting modification was successful. Furthermore, epoxy (EP)/GO composites were prepared, and the effects of unmodified GO and GO-SiO on the curing kinetics of EP were comparatively studied by differential scanning calorimetry (DSC).

Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.

Background: Ligustrazine is a traditional Chinese herbal medicine that has long been used to treat cerebral ischemic disorders. However, the molecular mechanisms of ligustrazine in cerebral ischemia/reperfusion (I/R) damage have not been clear elucidated. The aim of this study was to examine the neuroprotective mechanisms of ligustrazine in cerebral I/R.

The construction of neurogenesis-related ceRNA network of ischemic stroke treated by oxymatrine.

Background: Known as a disease associated with high mortality, disability and a significant financial burden, ischemic stroke ranks as one of the three diseases threatening human health. Recent advances in omics technology created opportunities to uncover the mechanism in ischemic stroke occurrence and treatment. In this study, we aimed to construct the competitive endogenous RNA (ceRNA) networks of ischemic stroke treated by oxymatrine intervention.

Evaluation of Blend Uniformity and Terminal Point during Continuous Mixing in Water for Modified Double-Base Propellant Components Using a Near-Infrared Method.

A near-infrared (NIR) spectrometer was used to test the double-base absorbent powder sample and to quantitatively analyze the contents of each component as well as their dispersion uniformity to establish a rapid quantitative test method for blending uniformity of modified double-base (MDB) propellant components. First, the quantitative calibration models of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) were constructed based on sample testing, and the RDX model's correlation coefficient was 0.9929.

Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke.

Acute ischemic stroke (AIS) is a severe neurological disease with complex pathophysiology, resulting in the disability and death. The goal of this study is to explore the underlying molecular mechanisms of AIS and search for new potential biomarkers and therapeutic targets. Integrative analysis of mRNA and miRNA profiles downloaded from Gene Expression Omnibus (GEO) was performed.

Visual Perception Generalization for Vision-and-Language Navigation via Meta-Learning.

Vision-and-language navigation (VLN) is a challenging task that requires an agent to navigate in real-world environments by understanding natural language instructions and visual information received in real time. Prior works have implemented VLN tasks on continuous environments or physical robots, all of which use a fixed-camera configuration due to the limitations of datasets, such as 1.5-m height, 90° horizontal field of view (HFOV), and so on.

Circulating miRNA-3552 as a Potential Biomarker for Ischemic Stroke in Rats.

Objective: With the growing incidence of ischemic stroke worldwide, there is an urgent need to identify blood biomarkers for ischemic stroke patients. Thus, our aim was to identify potential circulating microRNA (miRNA) as a potential biomarker and to explore its potential mechanism for ischemic stroke in rats.

Methods: The mRNA dataset GSE97537 and miRNA dataset GSE97532 were downloaded from the Gene Expression Omnibus (GEO) GSE97537 including 7 middle cerebral artery occlusion (MCAO) rat brain tissues and 5 sham-operated rat brain tissues GSE97532 including 6 MCAO rat blood samples and 3 sham-operated rat blood samples.

Impact of Nb(V) Substitution on the Structure and Optical and Photoelectrochemical Properties of the Cu(TaNb )O Solid Solution.

A family of solid solutions, Cu(TaNb )O (0 ≤ x ≤ 0.4), was investigated as p-type semiconductors for their band gaps and energies and for their activity for the reduction of water to molecular hydrogen. Compositions from 0 to 40 mol % niobium were prepared in high purity by solid-state methods, accompanied by only very small increases in the lattice parameters of ∼0.

Theoretical study on crystal morphologies of 1,1-diamino-2,2-dinitroethene in solvents: Modified attachment energy model and occupancy model.

In this study, the growth morphologies of 1,1-diamino-2,2-dinitroethene (FOX-7) in vacuum and solvent conditions were investigated by molecular dynamics simulation. The modified attachment energy (MAE) model and occupancy model were used separately to predict the crystal morphology by calculating relative growth rate of different crystal faces in HO/NMP and DMSO/AC solvent system. The calculated results show that the (0 1 1) face and (1 0 1) face are the most important crystal face in both two solvents towards the MAE model and the occupancy model, respectively.

Wavelength dependent photochemical charge transfer at the CuO-BiVO particle interface - evidence for tandem excitation.

The understanding of the photochemical charge transfer properties of powdered semiconductors is of relevance to artificial photosynthesis and the production of solar fuels. Here we use surface photovoltage spectroscopy to probe photoelectrochemical charge transfer between bismuth vanadate (BiVO4) and cuprous oxide (Cu2O) particles as a function of wavelength and film thickness. Optimized conditions produce a -2.

Magnetometer and Gyroscope Calibration Method with Level Rotation.

Micro electro mechanical system (MEMS) gyroscopes and magnetometers are usually integrated into a sensor module or chip and widely used in a variety of applications. In existing integrated gyroscope and magnetometer calibration methods, rotation in all possible orientations is a necessary condition for a good calibration result. However, rotation around two or more axes is difficult to attain, as it is limited by the range of movement of vehicles such as cars, ships, or planes.

Surface Photovoltage Measurements on a Particle Tandem Photocatalyst for Overall Water Splitting.

Surface photovoltage spectroscopy (SPS) is used to measure the photopotential across a Ru-SrTiO:Rh/BiVO particle tandem overall water splitting photocatalyst. The tandem is synthesized from Ru-modified SrTiO:Rh nanocrystals and BiVO microcrystals by electrostatic assembly followed by thermal annealing. It splits water into H and O with an apparent quantum efficiency of 1.

Interactions between poly-(phthalazinone ether sulfone ketone) (PPESK) and TNT or TATB in polymer bonded explosives: a molecular dynamic simulation study.

The glass transition temperature (T ) and density of poly-(phthalazinone ether sulfone ketone) (PPESK A) were estimated by molecular dynamic (MD) simulation. A novel poly-(phthalazinone ether sulfone ketone) (PPESK B) was constructed by introducing nitrol and amini energetic groups into PPESK A, and T and density were also simulated for PPESK B. The estimated T values of PPESK A were very close to experimental results, while for PPESK B three estimated values differed by < 5 K.