A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy.

Cancer metastases and recurrence after surgical resection remain an important cause of treatment failure. Here we demonstrate a general strategy to fabricate personalized nanovaccines based on a cationic fluoropolymer for post-surgical cancer immunotherapy. Nanoparticles formed by mixing the fluoropolymer with a model antigen ovalbumin, induce dendritic cell maturation via the Toll-like receptor 4 (TLR4)-mediated signalling pathway, and promote antigen transportation into the cytosol of dendritic cells, which leads to an effective antigen cross-presentation.

Facile Preparation of CuSe Nanosheets as Dual-Functional Antibacterial Agents.

The spread of antibiotic-resistance poses a great threat, making it a growing need to develop other antibacterial strategies and therapeutics. Recently, owing to their excellent physicochemical properties, copper chalcogenides have received extensive attention as photothermal agents. However, most reports are focused on CuS nanoparticles, whereas very few water-dispersible CuSe nanomaterials have been reported due to their difficult preparation process.

Cell-Penetrating Peptide Enhanced Antigen Presentation for Cancer Immunotherapy.

The development of effective cancer vaccines is an important direction in the area of cancer immunotherapy. Although certain types of preventive cancer vaccines have already been used in the clinic, therapeutic cancer vaccines for treatment of already established tumors are still in high demand. In this study, we develop a new type of cancer vaccine by mixing cell-penetrating peptide (CPP) conjugated antigen as the enhanced antigen, together with CpG as the immune adjuvant.