Publications by authors named "Zongjie Jin"
Background: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons, abnormal accumulation of α-synuclein (α-syn), and microglial activation. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates multiple functions of microglia in the brain, and several studies have shown that TREM2 variant R47H is a risk factor for PD. However, the regulation of microglia by TREM2 in PD remains poorly understood.
View Article and Find Full Text PDFNeuroinflammation and autoimmunity are pivotal in the pathogenesis of neurodegenerative diseases. Complement activation and involvement of astrocyte-neuron C3/C3aR pathway have been observed, yet the mechanisms influencing α-synuclein (α-syn) pathology and neurodegeneration remain unclear. In this study, elevated levels of complement C3 were detected in the plasma of α-syn PFF-induced mice and the substantia nigra of A53T transgenic mice.
View Article and Find Full Text PDFIntroduction: Microglia are the main phagocytes in the brain and can induce neuroinflammation. Moreover, they are critical to alpha-synuclein (α-syn) aggregation and propagation. Plasma exosomes derived from patients diagnosed with Parkinson's disease (PD-exo) reportedly evoked α-syn aggregation and inflammation in microglia.
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- Mitochondria and lysosomes interact closely to maintain cell health, impacting metabolism, organelle behavior, and stress responses, with disruptions linked to neurodegenerative diseases.
- Under stress, dysfunction in mitochondria and lysosomes can occur, hindering processes like autophagy and increasing the release of exosomes in brain cells.
- The review discusses how understanding these cellular interactions can lead to new nanomedicine strategies to treat neurodegenerative diseases effectively.
Circadian rhythms are involved in the regulation of many aspects of the body, including cell function, physical activity and disease. Circadian disturbance often predates the typical symptoms of neurodegenerative diseases and is not only a non-motor symptom, but also one of the causes of their occurrence and progression. Glial cells possess circadian clocks that regulate their function to maintain brain development and homeostasis.
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- Parkinson's disease (PD) is a rapidly growing neurological disorder characterized by the loss of dopamine-producing neurons, leading to both motor and non-motor symptoms, and current therapies do not halt disease progression.
- Emerging treatments focus on regenerating dopaminergic neurons through cell transplantation and innovative approaches like reprogramming astrocytes, despite challenges related to ethical concerns and cell sources.
- The review emphasizes advances in reprogramming astrocytes using transcription factors and miRNAs, and highlights potential neuroprotective strategies by targeting mitochondrial health and inflammation in astrocytes to combat PD.