Publications by authors named "Zongjiang Zhou"

Background: Neoadjuvant chemotherapy, particularly the use of platinum-based compounds and taxanes, is pivotal in the treatment of epithelial-derived tumors, such as cervical cancer and esophageal squamous cell carcinoma (ESCC); however, resistance remains a significant challenge. Utilizing Mendelian randomization (MR) with pharmacogenomics offers a novel approach to understanding the genetic underpinnings of drug responses, thereby aiding in personalized treatment.

Methods: Single-cell RNA sequencing (scRNA-seq) analysis revealed a shared cellular subpopulation of CD8 + T effector memory (CD8 + TEM) cells that are pivotal in mediating chemotherapy resistance in ESCC and cervical cancer.

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Article Synopsis
  • Endoplasmic reticulum stress (ERS) plays a crucial role in inflammatory bowel disease (IBD) and the research aimed to identify molecular markers related to ERS and inflammation, focusing on risk factors and high-risk patient groups.
  • Using statistical methods like LASSO and logistic regression, the study created a predictive model that categorized IBD patients and discovered four gene clusters, revealing significant differences in gene expression and immune functions between high-risk and low-risk groups.
  • A key gene was identified as a strong predictor for IBD with potential as a diagnostic marker and therapeutic target, highlighting the need for personalized therapy based on the new ERS-associated gene model in IBD management.
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Metabolic reprogramming is an essential hallmark of tumors, and metabolic abnormalities are strongly associated with the malignant phenotype of tumor cells. This is closely related to transcriptional dysregulation. Super-enhancers are extremely active cis-regulatory regions in the genome, and can amalgamate a complex set of transcriptional regulatory components that are crucial for establishing tumor cell identity, promoting tumorigenesis, and enhancing aggressiveness.

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Esophageal cancer, known for its high incidence and low five-year survival rate, poses significant treatment challenges. A key aspect of this challenge is the close link between mitochondria and resistance to chemoradiotherapy (CRT). Currently, there is a scarcity of biomarkers for predicting CRT response and prognosis in esophageal cancer.

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  • * Key interactions involve changes in cell behavior like epithelial-mesenchymal transformation, disruptions in iron metabolism in cancer stem cells, macrophage polarization, and the impact of iron levels on immune responses and blood vessel formation.
  • * The review emphasizes how microRNAs related to ferroptosis can influence tumor metastasis by affecting cancer and immune cell interactions, cytokine regulation, and angiogenesis, presenting new avenues for potential cancer treatments.
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Tumor metastasis is an important factor that contributes to the poor prognosis of patients with tumors. Therefore, to solve this problem, research on the mechanism of metastasis is essential. Ferroptosis, a new mode of cell death, is characterized by membrane damage due to lipid peroxidation caused by iron overload.

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