Corrigendum: The effect and mechanism of volatile oil emulsion from leaves of (Lour.) Skeels on .

[This corrects the article DOI: 10.3389/fmicb.2024.

Adult Hymenolepis nana and its excretory-secretory products elicit mouse immune responses via tuft/IL-13 and FOXM1 signaling pathways.

Background: Hosts typically elicit diverse immune responses to the infection of various parasitic worms, with intestinal epithelial cells playing pivotal roles in detecting parasite invasion. Hymenolepis nana (H. nana) is a zoonotic parasitic worm that resides in the host's intestine.

Integrated bulk RNA sequencing and mass cytometry analysis reveal the circulating immune landscape in ischemic and hemorrhagic Moyamoya disease.

Background: Moyamoya disease (MMD) is increasingly recognized as being influenced by chronic inflammation, with circulating immune cells playing a role in its progression. However, research on the immune characteristics of different MMD subtypes is limited. This study aims to compare the peripheral immune profiles of ischemic and hemorrhagic MMD patients.

A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells.

Zika virus (ZIKV) is spread by mosquito bites and is unique among known flaviviruses for being able to cause microcephaly. Entry factors for ZIKV are incompletely understood, but phosphatidylserine (PS) receptors, including the TAM (Tyro3, AXL, and Mer) and TIM (T-cell Ig mucin) families, can serve as cofactors for flavivirus entry in a cell type-specific manner. We identify AXL as the top hit in a CRISPR/Cas9 genome-wide screen in human glioblastoma cells and establish a definitive role of AXL, but not TYRO3 or MerTK, for ZIKV infection.

Correlation Between the Quality of Life of Stroke Caregivers and the Readiness of Patients and Caregivers for Hospital Discharge.

Objective: This study aimed to evaluate the quality of life of stroke caregivers and analyze its association with the discharge readiness of both caregivers and patients.

Methods: A total of 302 stroke patients and their primary caregivers were recruited from the neurology departments of three hospitals affiliated with Chengdu Medical College using a convenience sampling method. Sociodemographic data, the WHO Quality of Life Scale (WHOQOL-BREF), the Caregiver Preparedness Scale (CPS), and the Readiness for Hospital Discharge Scale (RHDS) were used.

Traditional Chinese medicine as a protective strategy against chemotherapy-induced cardiotoxicity: An overview of the literature.

Cardiotoxicity refers to the damage caused to the heart or vascular system, which has become a significant cause of morbidity and mortality worldwide. Up to 20 % of adults undergoing cancer treatment may experience cardiotoxicity, with 7 %-10 % developing cardiomyopathy or heart failure. Cardiotoxic medications put patients at risk for a variety of heart conditions, including cardiac failure (HF), left ventricle (LV) systolic malfunction, cardiac arrhythmia, hypertension, coronary artery disease (CAD), and ischemia/myocardial infarction.

An Oxidative Stress Nanoamplifier with Efficient Non-Fenton-Type Hydroxyl Radical Generation and Sulfur Dioxide Release for Synergistic Treatment of Tumor.

Overcoming tumor antioxidant defenses remains a critical challenge for reactive-oxygen-species-mediated tumor therapies. To address this problem, herein, a theranostic nanomedicine designated as CCM@MIB has been elaborately constructed. Homologous cancer cell membrane (CCM) camouflage significantly enhances the selective accumulation of the nanomedicine at tumor sites.

Did a national extended access scheme translate to improvements in patient experience to GP services in England? A retrospective observational study using patient-level data from the English GP patient survey.

Background: Improving access to general practitioner (GP) services is seen as a way to enhance patients' experiences. England introduced the national extended access scheme to provide routine and urgent GP appointments outside core hours. However, little is known about how this initiative affects patient experience, especially in terms of efficiency and equity.

The association between speech impairments and depression in Chinese adults aged 45 and older: insights from the CHARLS database.

Background: Speech impairments significantly affect communication and are associated with social and psychological difficulties, particularly among adults aged 45 years and older. This study examines the relationship between speech impairments and depression using data from the China Health and Retirement Longitudinal Study (CHARLS).

Methods: A total of 67,014 participants aged 45 years and older were included in the analysis.

Curzerene Induces Apoptosis in Colorectal Cancer Cells Through Inhibition of MEK/ERK Signaling Pathway.

Objective: To investigate the anticancer activity of curzerene in colorectal cancer (CRC) in vitro and in vivo models.

Methods: HT29 and HCT8 cells were treated with different concentrations of curzerene (0, 20, 40, and 60 µg/mL) for 24 h. Cell viability was assessed using cell counting kit 8 assay, and cell proliferation was detected by colony-formation, then apoptosis rate was assessed by flow cytometry analysis.

Integrated Analysis to Reveal Heterogeneity of Tumor-Associated Neutrophils in Glioma.

Background: Glioma, characterized by its cellular and molecular heterogeneity, presents formidable challenges in treatment strategy and prognostic assessment. The tumor microenvironment (TME) profoundly influences tumor behavior and treatment response, with tumor-associated neutrophils (TANs) playing a complex but understudied role. This study aimed to investigate the heterogeneity and role of TANs in glioma and to develop a prognostic model.

Single-cell genomics and spatial transcriptomics in islet transplantation for diabetes treatment: advancing towards personalized therapies.

Diabetes mellitus (DM) is a global health crisis affecting millions, with islet transplantation emerging as a promising treatment strategy to restore insulin production. This review synthesizes the current research on single-cell and spatial transcriptomics in the context of islet transplantation, highlighting their potential to revolutionize DM management. Single-cell RNA sequencing, offers a detailed look into the diversity and functionality within islet grafts, identifying specific cell types and states that influence graft acceptance and function.

Unraveling the extensive phylogenetic discordance and evolutionary history of spurless taxa within the Aquilegia ecalcarata complex.

Parallel evolution of the same, or at least very similar, phenotype(s) in different lineages is often interpreted as evidence for the action of natural selection. However, caution is required when inferring parallel evolution based on uncertain or potentially incorrect phylogenetic frameworks. Here, by conducting extensive phylogenomic and population genetic analyses, we aim to clarify the evolutionary history of spurless taxa within the Aquilegia ecalcarata complex.

Knowledge-guided diffusion model for 3D ligand-pharmacophore mapping.

Pharmacophores are abstractions of essential chemical interaction patterns, holding an irreplaceable position in drug discovery. Despite the availability of many pharmacophore tools, the adoption of deep learning for pharmacophore-guided drug discovery remains relatively rare. We herein propose a knowledge-guided diffusion framework for 'on-the-fly' 3D ligand-pharmacophore mapping, named DiffPhore.

Unravelling the mechanism of coloration and prolonged discoloration in abnormally thermochromic PDMS nanocomposites.

Traditional thermochromic materials prioritize high sensitivity and rapid discoloration. Reversible thermochromism with delayed discoloration is highly desirable for applications like thermal history indicators and energy-saving windows, yet it has rarely been achieved. Here, we construct such thermochromic composites simply by assembling hydrophobic silica nanoparticles in a polydimethylsiloxane (PDMS) matrix.

Na+/K+-ATPase: a multifunctional target in type 2 diabetes and pancreatic islets.

Type 2 diabetes (T2D) is a widespread metabolic disorder marked by hyperglycemia, arising from insulin resistance and relative insulin deficiency. This review investigates the critical role of Na+/K+-ATPase (NKA), a transmembrane protein essential for maintaining cellular ion gradients, in the pathophysiology of T2D. We provide an overview of NKA's biological functions, emphasizing its involvement in cellular signaling pathways, insulin secretion, and glucose homeostasis.

Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring the need for early diagnosis to improve patient outcomes. Tumor-derived exosomes, which can be non-invasively obtained and reflect the metabolic state of tumors in real-time, are under increasing investigation for their diagnostic potential. Herein we analyzed metabolite differences in exosomes, serum, and tissues from patients with HNSCC to identify potential diagnostic biomarkers of clinical relevance.

Metagenomic analysis of pathogenic microorganisms in bloodstream infections following venomous snakebites.

Purpose: This study aimed to investigate the biometric characterization of pathogenic microorganisms associated with bloodstream infections in patients bitten by venomous snakes, and to determine whether the composition of these microorganisms influences the effects of snake venom.

Methods: The composition and relative abundance of microorganisms were statistically analyzed using metagenomic next-generation sequencing (mNGS) on blood samples from patients with varying degrees of snakebite injuries. These patients were admitted to the our study.

Low-dose acrylamide induces mitochondrial autophagy and energy metabolism dysfunction in SH-SY5Y cells via BV2 microglial activation.

Acrylamide (ACR), a common environmental and food contaminant, can cause neurotoxicity and increase the risk of neurodegenerative diseases. While the neurotoxicity induced by high-dose ACR exposure in occupational workers is evident, the potential adverse effects of low-dose daily exposure remain a subject of debate. In this present study, we aim to explore whether low-dose ACR induces neurotoxicity based on the interactions between microglia and neurons.

Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque.

Background: Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to the progression of atherosclerosis (AS). Meanwhile, Spermine (Sp) could serve as an endogenous small molecule exhibiting a wide range of cardiovascular protective effects.

Methods: Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were synthesized and utilized to create a novel delivery nanosystem encapsulated with Sp (CD16/32-ZIF90@Sp).

Rethinking Data Augmentation for Single-Source Domain Generalization in OCT Image Segmentation.

Domain shifts between samples acquired with different instruments are one of the major challenges in accurate segmentation of Optical Coherence Tomography (OCT) images. Given that OCT images may be acquired with different devices in different clinical centers, this study presents astyle and structure data augmentation (SSDA) method to improve the adaptability of segmentation models. Inspired by our initial analysis of OCT domain differences, we propose an innovative hypothesis that domain shifts are primarily due to differences in image style and anatomical structure, which further guides the design of our method.

Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis.

Background: Kidney fibrosis, the excessive accumulation and dysregulated remodeling of the extracellular matrix, is the principal pathophysiological process in chronic kidney disease (CKD). Protein L-isoaspartyl/D-aspartyl methyltransferase (PCMT1) is crucial in repairing post-translational modifications of L-isoaspartyl residues, which are important for extracellular matrix proteins because of their low turnover rate and susceptibility to accelerating factors. This study aimed to reveal a novel role of PCMT1 in kidney fibrosis.

Regulating Asymmetric Charge Distribution in CuMoS Nanosheets for Enhanced Photocatalytic CO Reduction.

Photocatalytic reduction of CO to high-value-added chemicals represents a promising strategy for effective CO utilization, and rationally regulating the electronic structure of the catalyst is the key to enhancing photocatalytic performance. Herein, it is demonstrated that in situ doping of atomic indium into the lattice of the CuMoS catalyst results in remarkable enhancements in photocatalytic CO reduction performance. A record gas product yield of 104.

Harnessing oleaginous protist Schizochytrium for docosahexaenoic acid: Current technologies in sustainable production and food applications.

Docosahexaenoic acid (DHA) exerts versatile roles in nutrition supplementation and numerous health disorders prevention. Global consumption demand for DHA has also been consistently increasing with enhanced health awareness. Oleaginous marine protist Schizochytrium is praised as a potential DHA source due to short growth cycle, convenient artificial culture, harmless to the human body, and easy manipulation of the DHA synthesis pathway.