An antioxidant, antibacterial, and immunoregulatory konjac glucomannan-based nanocomposite hydrogel for promoting skin wound healing.

Managing open skin wounds remains a notable challenge in clinical practice, with wound dressings gradually becoming an essential strategy for such treatment. To effectively regulate the wound healing microenvironment, we developed an antibiotic-free nanocomposite hydrogel by combining guanosine-based supramolecular G-quadruplexes (G4), angiogenic deferoxamine (DFO), konjac glucomannan (KGM), and zinc ions through a one-pot mixing strategy. The borate esters in G4 endow the hydrogel with a strong radical-scavenging ability.

Self-Assembled Hybrid Nanogel as a Multifunctional Theranostic Probe for Enzyme-Regulated Ultrasound Imaging and Tumor Therapy.

Multifunctional theranostic nanoprobes integrated with stimuli-responsive imaging and therapeutic capabilities have shown great potential to enhance the early cancer diagnostic efficacy and therapeutic efficiency. Elevated levels of lactate and hydrogen peroxide have been considered as the characteristic feature of the tumor microenvironment and can thus be exploited for developing promising theranostic strategies. We demonstrate here that the biocompatible and responsive enzyme-based nanogel probe has been designed as a promising theranostic tool to target high lactate and hydrogen peroxide for ultrasound imaging (US) and cancer treatment.

Total Glucosides of Paeony Alleviate Cell Apoptosis and Inflammation by Targeting the Long Noncoding RNA XIST/MicroRNA-124-3p/ITGB1 Axis in Renal Ischemia/Reperfusion Injury.

Objective: Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action.