Publications by authors named "Zonghui Qiao"
Study Question: The objective was to construct a model for predicting the probability of recurrent implantation failure (RIF) after assisted reproductive technology (ART) treatment based on the clinical characteristics and routine laboratory test data of infertile patients. A model was developed to predict RIF. The model showed high calibration in external validation, helped to identify risk factors for RIF, and improved the efficacy of ART therapy.
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- The study investigates whether quercetin can reduce fibrogenic responses in endometrial stromal cells by boosting microRNA-145 (miR-145) levels and affecting the TGFβ1/Smad2/Smad3 signaling pathway, aiming to find new treatment strategies for endometrial fibrosis.
- Methods included measuring the expression of miR-145 and TGFβ receptor 2 (TGFBR2) using RT-qPCR, assessing proteins related to fibrosis with immunofluorescence and western blot, and using dual-luciferase reporter assays to confirm the interaction between miR-145 and TGFBR2.
- Results showed that quercetin effectively upregulates miR