Asymmetric Total Synthesis and Structural Revision of DAT, an Antigenic Glycolipid from Mycobacterium tuberculosis.

DAT is a member of the diacyl trehalose family (DAT) of antigenic glycolipids located in the mycomembrane of Mycobacterium tuberculosis (Mtb). Recently it was shown that the molecular structure of DAT had been incorrectly assigned, but the correct structure remained elusive. Herein, the correct molecular structure of DAT and its methyl-branched acyl substituent mycolipanolic acid is determined.

Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design.

This study aims to investigate active phytochemicals isolated from Pyrola incarnata Fisch. (P. incarnata) and their protection against neuroinflammation induced by LPS.

Antioxidant activity against HO-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves.

Context: The leaves of Pyrola decorate H. Andr (Pyrolaceae), known as Luxiancao, have long been used for treating kidney deficiency, gastric haemorrhage and rheumatic arthritic diseases in traditional Chinese medicine.

Objective: The phytochemicals and antioxidant capacities in vitro of P.